2008
DOI: 10.1089/rej.2008.0718
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Identifying the Changes in Gene Profiles Regulating the Amelioration of Age-Related Oxidative Damages in Kidney Tissue of Rats by the Intervention of Adult-Onset Calorie Restriction

Abstract: This study was initiated to investigate gene expression profiles that are involved in the molecular mechanisms regulating the amelioration of age-related oxidative damages in male Fischer-344 rats (12 months) through adult-onset calorie restriction (CR) intervention for 6 months. The adult-onset CR was initiated with 10 and 25% restriction for the first and second weeks, respectively, and then maintained at 40% throughout the experiment. The adult-onset CR significantly (p < 0.05) decreased urinary 8-isoprosta… Show more

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Cited by 10 publications
(7 citation statements)
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“…In addition, these observations were admittedly subject to our own interpretation of the reported data. The protective effects of DR in aging and disease are likely mediated by a number of mechanisms, including prevention of apoptosis in post-mitotic cells [210212], preservation of stem cell function [213], reducing inflammation [138, 151, 214216], hormesis [217], and reducing senescent cells [173]. As the redox stress theory of aging points out, oxidative modifications are often more than just damage and can affect function.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, these observations were admittedly subject to our own interpretation of the reported data. The protective effects of DR in aging and disease are likely mediated by a number of mechanisms, including prevention of apoptosis in post-mitotic cells [210212], preservation of stem cell function [213], reducing inflammation [138, 151, 214216], hormesis [217], and reducing senescent cells [173]. As the redox stress theory of aging points out, oxidative modifications are often more than just damage and can affect function.…”
Section: Discussionmentioning
confidence: 99%
“…This similarity in sodium between the LP-AL and HP-CR groups was confirmed by sodium excretion, which showed no differences. The proteinuria-reducing effect of CR has been demonstrated in several previous studies (Chen et al, 2008;Davis et al, 1983;Gumprecht et al, 1993;Keenan et al, 2000;Klooster, 2013;McKiernan et al, 2007;Wiggins et al, 2005;Xu et al, 2015). Most of these studies induced CR at a young age before the onset of renal dysfunction (Keenan et al, 2000;Wiggins et al, 2005).…”
Section: Lower Number Of Glomerular Macrophages In Cr-treated Animalsmentioning
confidence: 87%
“…Furthermore, Sohal and colleagues (1994) compared AL and CR mice at nine, seventeen and twenty-three months of age and found that protein carbonyl content in the kidney and heart increased with age and was significantly reduced by CR in both tissues at each of the three ages (18). In addition, CR was found to reduce the protein carbonylation in the kidney of rats (19).…”
Section: Discussionmentioning
confidence: 99%