2020
DOI: 10.2196/16076
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Identifying the Characteristics of Patients With Cervical Degenerative Disease for Surgical Treatment From 17-Year Real-World Data: Retrospective Study

Abstract: Background Real-world data (RWD) play important roles in evaluating treatment effectiveness in clinical research. In recent decades, with the development of more accurate diagnoses and better treatment options, inpatient surgery for cervical degenerative disease (CDD) has become increasingly more common, yet little is known about the variations in patient demographic characteristics associated with surgical treatment. Objective This study aimed to ident… Show more

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Cited by 6 publications
(6 citation statements)
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“…483,484 Retrospective clinical analysis is the most commonly used computational approach based on RWD and the data are mainly obtained from EHRs. 485,486 A classic case of repurposing a noncancer drug for cancer treatment from retrospective clinical analysis is that of metformin which can decrease cancer mortality in a dose dependent manner. 487,488 Xu et al designed a clinical cohort from 15 years of EHRs from Vanderbilt University Medical Center and Mayo Clinic.…”
Section: Technological Approaches To Drug Repurposing For Cancer Therapymentioning
confidence: 99%
“…483,484 Retrospective clinical analysis is the most commonly used computational approach based on RWD and the data are mainly obtained from EHRs. 485,486 A classic case of repurposing a noncancer drug for cancer treatment from retrospective clinical analysis is that of metformin which can decrease cancer mortality in a dose dependent manner. 487,488 Xu et al designed a clinical cohort from 15 years of EHRs from Vanderbilt University Medical Center and Mayo Clinic.…”
Section: Technological Approaches To Drug Repurposing For Cancer Therapymentioning
confidence: 99%
“…Therefore, STEF can capture in detail the fine motor deficits characteristic of CSM and correlate with the JOA score [ 9 , 10 ]. In recent years, the length of hospital stay for spine surgery has been shortened in Japan and other countries to address medical cost issues [ 11 , 12 ]. It is challenging to predict outcomes after a short hospital stay.…”
Section: Introductionmentioning
confidence: 99%
“…The retrospective clinical trial analysis is a commonly used computational approach based on RWD, with data commonly extracted from EHRs ( Gray et al, 2019 ; Zheng et al, 2020 ). Sildenafil is an interesting example of retrospective clinical analysis which led to the repurposing of a candidate molecule ( Ashburn and Thor, 2004 ).…”
Section: Approaches Used For Drug Repurposing In Cancer Therapymentioning
confidence: 99%