Identifying the early predictors of non-response to steroids in patients with flare of autoimmune hepatitis causing acute-on-chronic liver failure

Sharma, Sanchit; Agarwal, Samagra; Saraya, Anoop; Choudhury, Ashok; Saigal, Sanjiv; Soin, Arvinder S.; Shukla, Akash; Sahu, Manoj Kumar; Lesmana, Laurentius A; Lesmana, Renaldi C; Shah, Samir; Hu, Jinhua; Tan, Soek Siam; Jothimani, Dinesh; Rela, Mohammed; Ghazinyan, Hasmik; Amrapurkar, Deepak; Eapen, C E; Goel, Ashish; Payawal, Diana; Salehiniya, Hamid; Butt, Amna Subhan; Duan, Zhongping; Singh, Virender; Duseja, Ajay; Sood, Ajit; Midha, Vandana; Mahtab, Mamun Al; Kim, Dong Joon; Ning, Qin; Kulkarni, Anand V.; Rao, Padaki Nagaraja; Lee, Guan Huei; Treeprasertsuk, Sombat; Xin, Shaojie; Karim, Md. Fazal; Sollano, José D.; Kalista, Kemal Fariz; Gani, Rino Alvani; Prasad, V G Mohan; Sarin, Shiv Kumar

doi:10.1007/s12072-023-10482-4

Cited by 3 publications

(1 citation statement)

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“…Patients with AIH-related ACLF present histological features typical of AIH, including perivenulitis, lymphoid aggregates, and massive hepatic necrosis (132). The development of VH in patients with ACLF is an independent predictor of mortality (133). Acute hepatic venous outflow tract obstruction (HVOTO) or PVT can present as ACLF as per APASL guidelines (91).…”

Section: Precipitating Events In Aclfmentioning

confidence: 99%

Pathophysiology and management of liver cirrhosis: from portal hypertension to acute-on-chronic liver failure

Jagdish¹,

Roy

Kumar

et al. 2023

Front. Med.

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Cirrhosis transcends various progressive stages from compensation to decompensation driven by the severity of portal hypertension. The downstream effect of increasing portal hypertension severity leads to various pathophysiological pathways, which result in the cardinal complications of cirrhosis, including ascites, variceal hemorrhage, and hepatic encephalopathy. Additionally, the severity of portal hypertension is the central driver for further advanced complications of hyperdynamic circulation, hepatorenal syndrome, and cirrhotic cardiomyopathy. The management of these individual complications has specific nuances which have undergone significant developments. In contrast to the classical natural history of cirrhosis and its complications which follows an insidious trajectory, acute-on-chronic failure (ACLF) leads to a rapidly downhill course with high short-term mortality unless intervened at the early stages. The management of ACLF involves specific interventions, which have quickly evolved in recent years. In this review, we focus on complications of portal hypertension and delve into an approach toward ACLF.

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Section: Precipitating Events In Aclfmentioning

confidence: 99%