Identifying the patient with heart failure to be treated with vericiguat

Cervantes, C. Escobar; Fernández, Alberto Esteban; Mayoral, Alejandro Recio; Mirabet, Sònia; Costello, José González; Gracia, Jorge; Núñez, Julio; Franco, Álvaro González; Palomas, Juan Luis Bonilla

doi:10.1080/03007995.2023.2189857

Cited by 3 publications

(1 citation statement)

References 65 publications

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“…Endothelial NO controls vascular dilation, thus, is relevant to the function of all organs and systems [74]. Larger post occlusion flow-mediated dilation, in fact, is considered a predictor of less vulnerability to cardiovascular events [75], and drugs containing NO donors are administered in clinical trials [76]. Moreover, NO exerts a central inhibition of the sympathetic activity [77], which is increased in patients with heart failure [78].…”

Section: Cardiovascular Controlmentioning

confidence: 99%

Physiological Correlates of Hypnotizability: Hypnotic Behaviour and Prognostic Role in Medicine

Malloggi,

Santarcangelo

2023

Brain Sciences

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Studies in the field of experimental hypnosis highlighted the role of hypnotizability in the physiological variability of the general population. It is associated, in fact, with a few differences which are observable in the ordinary state of consciousness and in the absence of suggestions. The aim of the present scoping review is summarizing them and indicate their relevance to the neural mechanisms of hypnosis and to the prognosis and treatment of a few medical conditions. Individuals with high, medium and low hypnotizability scores display different cerebral functional differences—i.e., functional equivalence between imagery and perception/action, excitability of the motor cortex, interoceptive accuracy—possibly related to brain structural and functional characteristics, and different control of blood supply at peripheral and cerebral level, likely due to different availability of endothelial nitric oxide. These differences are reviewed to support the idea of their participation in hypnotic behaviour and to indicate their prognostic and therapeutic usefulness in a few medical conditions.

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Section: Cardiovascular Controlmentioning

confidence: 99%

Physiological Correlates of Hypnotizability: Hypnotic Behaviour and Prognostic Role in Medicine

Malloggi,

Santarcangelo

2023

Brain Sciences

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Clinical profile, associated events and safety of vericiguat in a real‐world cohort: The VERITA study

Galván Ruiz,

Fernández de Sanmamed Girón,

del Val Groba Marco

et al. 2024

ESC Heart Failure

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AimsThe aim of this study was to determine the clinical profile, associated events and safety of vericiguat in a real‐world cohort of patients with heart failure with reduced ejection fraction (HFrEF).MethodsThis study is a prospective and observational cohort study of patients with HFrEF and recent HF worsening episodes requiring intravenous therapy who initiated vericiguat in an HF outpatient clinic. A subanalysis of patients with ≥6 months' follow‐up was performed separately.ResultsOut of 103 patients initially included, 52 had a follow‐up of at least 6 months (median follow‐up of 303 days). At baseline, the mean age was 71.3 ± 9.4 years, 27.2% were women, the median left ventricular ejection fraction was 34% (28%–39%) and 99% were taking beta‐blockers, 96.1% sodium‐glucose cotransporter‐2 (SGLT2) inhibitors, 95.1% sacubitril–valsartan, 90.3% aldosterone antagonists and 93.2% loop diuretics. During follow‐up, New York Heart Association (NYHA) functional class improved (from 67.3% and 32.7% in classes III and II, respectively, to 22.4% and 75.5% at study end; P < 0.001), as did the EuroQol‐5D (EQ‐5D) and visual analogue scale (VAS) scores (from 0.83 ± 0.13 to 0.87 ± 0.12, P = 0.032, and from 60 to 79, P = 0.005, respectively). Vericiguat was well tolerated (13.5% had symptomatic hypotension, and 11.5% had discontinued treatment), and 78.8% of patients achieved the target dose of 10 mg. The number of HF‐related hospitalizations/decompensations within the previous 12 months was 2.3 ± 1.4 and decreased with vericiguat to 0.79 ± 1.14 (P < 0.001). At study end, 7.7% died (50% for HF).ConclusionsIn clinical practice, treatment with vericiguat is associated with substantial improvements in functional class and quality of life and a reduction in hospitalizations for HF, with a low risk of adverse effects.

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Physiological Correlates of Hypnotizability: Neural Mechanisms of Hypnosis and Prognostic Role in Medicine

Malloggi,

Santarcangelo1

2023

Preprint

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Studies in the field of experimental hypnosis highlighted the role of hypnotizability in the physiological variability of the general population. It is associated, in fact, with a few differences which are observable in the ordinary state of consciousness and in the absence of suggestions. The aim of the present scoping review is summarizing them, and indicate their relevance to the neural mechanisms of hypnosis and to the prognosis and treatment of a few medical conditions. Individuals with high, medium and low hypnotizability scores display different cerebral functional differences – i.e., functional equivalence between imagery and perception/action, excitability of the motor cortex, interoceptive accuracy - possibly related to brain structural and functional characteristics -, and different control of blood supply at peripheral and cerebral level, likely due to different availability of endothelial nitric oxide. These differences are reviewed to support the idea of their participation in hypnotic behaviour and to indicate their prognostic and therapeutic usefulness in a few medical conditions.

show abstract

Identifying the patient with heart failure to be treated with vericiguat

Cited by 3 publications

References 65 publications

Physiological Correlates of Hypnotizability: Hypnotic Behaviour and Prognostic Role in Medicine

Physiological Correlates of Hypnotizability: Hypnotic Behaviour and Prognostic Role in Medicine

Clinical profile, associated events and safety of vericiguat in a real‐world cohort: The VERITA study

Physiological Correlates of Hypnotizability: Neural Mechanisms of Hypnosis and Prognostic Role in Medicine

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