Identifying the Role of GluN2A in Cerebral Ischemia

Sun, Yongjun; Wang, Long

doi:10.3389/fnmol.2017.00012

Cited by 5 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Modifications of the GluN2A-containing NMDARs have been implicated in several pathological conditions including among others cerebral ischemia [148], depression [149][150][151][152][153][154][155][156], anxiety [149,157], schizophrenia [158][159][160][161], and Huntington's disease [162][163][164]. In this review we decided to focus our attention on selected brain disorders in which GluN2A disfunctions is strictly correlated to altered synaptic plasticity, such as epilepsy, Alzheimer's disease, Parkinson's disease, Fragile-X Syndrome, and autism.…”

Section: Role Of Glun2a In Pathological Plasticitymentioning

confidence: 99%

Synaptic GluN2A-Containing NMDA Receptors: From Physiology to Pathological Synaptic Plasticity

Franchini

Carrano

Luca

et al. 2020

IJMS

View full text Add to dashboard Cite

N-Methyl-d-Aspartate Receptors (NMDARs) are ionotropic glutamate-gated receptors. NMDARs are tetramers composed by several homologous subunits of GluN1-, GluN2-, or GluN3-type, leading to the existence in the central nervous system of a high variety of receptor subtypes with different pharmacological and signaling properties. NMDAR subunit composition is strictly regulated during development and by activity-dependent synaptic plasticity. Given the differences between GluN2 regulatory subunits of NMDAR in several functions, here we will focus on the synaptic pool of NMDARs containing the GluN2A subunit, addressing its role in both physiology and pathological synaptic plasticity as well as the contribution in these events of different types of GluN2A-interacting proteins.

show abstract

Section: Role Of Glun2a In Pathological Plasticitymentioning

confidence: 99%

Synaptic GluN2A-Containing NMDA Receptors: From Physiology to Pathological Synaptic Plasticity

Franchini

Carrano

Luca

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…The three major NMDAR subtypes in the adult forebrain are the GluN1/2A receptors, the GluN1/2B receptors, and the GluN1/2A/2B receptors. 53 It is speculated that the investigation of GluN1/2A/2B receptors may provide a novel treatment strategy for several neurological diseases related to excitotoxicity. 54 However, NMDARs play a dual role in IS-related excitotoxicity.…”

Section: Neuronal Excitotoxitymentioning

confidence: 99%

Eriodictyol: a review of its pharmacological activities and molecular mechanisms related to ischemic stroke

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The developmental change that takes place from the diheteromeric GluN1/2B form of receptors to triheteromeric GluN1/2A/2B receptors [33] supports synaptic plasticity alterations and neuronal circuit maturation [34]. In addition, heterogeneity among NMDA receptor subunits and assemblage of various receptor subtypes that possess definite functional characteristics allow accurate synaptic response tuning and permit variations in physiological roles and functions of the receptors during neuronal development [35].…”

Section: Glun1/2a and Glun1/2b Diheteromer And Triheteromer Receptorsmentioning

confidence: 99%

GluN2A and GluN2B N-Methyl-D-Aspartate Receptor (NMDARs) Subunits: Their Roles and Therapeutic Antagonists in Neurological Diseases

Ladagu,

Olopade,

Adejare

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

N-methyl-D-aspartate receptors (NMDARs) are ion channels that respond to the neurotransmitter glutamate, playing a crucial role in the permeability of calcium ions and excitatory neurotransmission in the central nervous system (CNS). Composed of various subunits, NMDARs are predominantly formed by two obligatory GluN1 subunits (with eight splice variants) along with regulatory subunits GluN2 (GluN2A-2D) and GluN3 (GluN3A-B). They are widely distributed throughout the CNS and are involved in essential functions such as synaptic transmission, learning, memory, plasticity, and excitotoxicity. The presence of GluN2A and GluN2B subunits is particularly important for cognitive processes and has been strongly implicated in neurodegenerative diseases like Parkinson’s disease and Alzheimer’s disease. Understanding the roles of GluN2A and GluN2B NMDARs in neuropathologies provides valuable insights into the underlying causes and complexities of major nervous system disorders. This knowledge is vital for the development of selective antagonists targeting GluN2A and GluN2B subunits using pharmacological and molecular methods. Such antagonists represent a promising class of NMDA receptor inhibitors that have the potential to be developed into neuroprotective drugs with optimal therapeutic profiles.

show abstract

Identifying the Role of GluN2A in Cerebral Ischemia

Cited by 5 publications

References 17 publications

Synaptic GluN2A-Containing NMDA Receptors: From Physiology to Pathological Synaptic Plasticity

Synaptic GluN2A-Containing NMDA Receptors: From Physiology to Pathological Synaptic Plasticity

Eriodictyol: a review of its pharmacological activities and molecular mechanisms related to ischemic stroke

GluN2A and GluN2B N-Methyl-D-Aspartate Receptor (NMDARs) Subunits: Their Roles and Therapeutic Antagonists in Neurological Diseases

Contact Info

Product

Resources

About