Identifying the role of microRNAs in spinal cord injury

Dong, Jing; Lü, Meng; He, Xijing; Junkui, Xu; Qin, Jie; Zhang, Cheng; Liang, Baobao; Wang, Dong; Li, Haopeng

doi:10.1007/s10072-014-1940-0

Cited by 27 publications

(37 citation statements)

References 80 publications

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“…However, miR-124a expression is significantly decreased from day 1 to day 7 after injury [21]. In consistency with these findings, several other microRNAs profiling studies also suggest that abnormal expression of microRNAs may contribute to the pathogenesis of SCI [25–27]. …”

Section: Altered Micrornas Expression Following Scimentioning

confidence: 70%

Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury

Teng

Liu

2016

Neural Plasticity

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Spinal cord injury is a devastating disease which disrupts the connections between the brain and spinal cord, often resulting in the loss of sensory and motor function below the lesion site. Most injured neurons fail to regenerate in the central nervous system after injury. Multiple intrinsic and extrinsic factors contribute to the general failure of axonal regeneration after injury. MicroRNAs can modulate multiple genes' expression and are tightly controlled during nerve development or the injury process. Evidence has demonstrated that microRNAs and their signaling pathways play important roles in mediating axon regeneration and glial scar formation after spinal cord injury. This article reviews the role and mechanism of differentially expressed microRNAs in regulating axon regeneration and glial scar formation after spinal cord injury, as well as their therapeutic potential for promoting axonal regeneration and repair of the injured spinal cord.

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Section: Altered Micrornas Expression Following Scimentioning

confidence: 70%

Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury

Teng

Liu

2016

Neural Plasticity

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“…The elucidation of the pathophysiological mechanisms underlying SCI is necessary for studying effective therapies for SCI [10]. The research on miRNAs may provide new insights for the study of the molecular mechanisms of SCI [10]. In this study, we explored the effects of miR-494 on the proliferation of astrocytes and the synaptic remodeling in the spinal cord in a rat model of chronic compressive SCI through regulation of the Nogo/NgR signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

“…Improvements in the neurosciences have drawn more attention to SCI research, and until now, no available treatments for SCI could effectively decrease or stop the disease progression [1,22,23]. The elucidation of the pathophysiological mechanisms underlying SCI is necessary for studying effective therapies for SCI [10]. The research on miRNAs may provide new insights for the study of the molecular mechanisms of SCI [10].…”

Section: Discussionmentioning

confidence: 99%

Effects of MicroRNA-494 on Astrocyte Proliferation and Synaptic Remodeling in the Spinal Cord of a Rat Model of Chronic Compressive Spinal Cord Injury by Regulating the Nogo/Ngr Signaling Pathway

Wang

Sun

Wang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Chronic compression of the spinal cord causes the loss of motor neurons in the anterior horn, but the precise and extensive mechanism for the loss is not completely determined. Therefore, this study aims to explore the role of microRNA-494 (miR-494) in the proliferation of astrocytes and in the synaptic remodeling in the spinal cord of a rat model of chronic spinal cord injury (SCI) by regulating the Nogo/NgR signaling pathway. Methods: A rat model of chronic, compressive SCI was established, and the spinal cord state, blood supply changes, and astrocyte apoptosis were observed. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) and Western blotting were used to detect expression of miR-494 and the Nogo/NgR signaling pathway-related genes. Fluorescence in situ hybridization (FISH) was used for detecting miR-494 expression and distribution. Results: Higher miR-494 expression was accompanied by the inhibition of astrocyte proliferation and synaptic remodeling. In addition, CDK6 could be regulated by miR-494 and was shown to be one of the target genes of miR-494. Positive expression of miR-494 detected by FISH was consistent with the results from RT-qPCR that miR-494 could downregulate CDK6 gene expression. Moreover, the direct miR-494 target CDK6 plays important inhibitory roles in chronic SCI by suppressing the Nogo/ NgR signaling pathway. Conclusions: The results demonstrated that miR-494 inhibition can promote astrocyte proliferation and synaptic remodeling by suppressing the Nogo/NgR signaling pathway in a rat model of chronic SCI.

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“…In recent years, investigators have begun to document the potential effects that microRNA (miRNA) sequences may have on the regulation of the processes involved in SCI (7–9). The miRNA sequences are small, unique, non-coding RNA fragments that form hairpin structures averaging 22 nucleotides in length.…”

Section: Introductionmentioning

confidence: 99%

The Role of microRNA Markers in the Diagnosis, Treatment, and Outcome Prediction of Spinal Cord Injury

et al. 2016

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Spinal cord injury (SCI) is a devastating condition that affects many people worldwide. Treatment focuses on controlling secondary injury cascade and improving regeneration. It has recently been suggested that both the secondary injury cascade and the regenerative process are heavily regulated by microRNAs (miRNAs). The measurement of specific biomarkers could improve our understanding of the disease processes, and thereby provide clinicians with the opportunity to guide treatment and predict clinical outcomes after SCI. A variety of miRNAs exhibit important roles in processes of inflammation, cell death, and regeneration. These miRNAs can be used as diagnostic tools for predicting outcome after SCI. In addition, miRNAs can be used in the treatment of SCI and its symptoms. Significant laboratory and clinical evidence exist to show that miRNAs could be used as robust diagnostic and therapeutic tools for the treatment of patients with SCI. Further clinical studies are warranted to clarify the importance of each subtype of miRNA in SCI management.

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Identifying the role of microRNAs in spinal cord injury

Cited by 27 publications

References 80 publications

Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury

Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury

Effects of MicroRNA-494 on Astrocyte Proliferation and Synaptic Remodeling in the Spinal Cord of a Rat Model of Chronic Compressive Spinal Cord Injury by Regulating the Nogo/Ngr Signaling Pathway

The Role of microRNA Markers in the Diagnosis, Treatment, and Outcome Prediction of Spinal Cord Injury

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