2022
DOI: 10.1177/11769351221139252
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Identifying the Therapeutic and Prognostic Role of the CD8+ T Cell-Related Gene ALDH2 in Head and Neck Squamous Cell Carcinoma

Abstract: Head and neck squamous cell carcinoma (HNSC) is a widely known malignancy which is usually diagnosed late and has a poor prognosis. This study focuses on finding a new gene linked with CD8+ T cell infiltration as a prognostic marker for patients with HNSC. Differential analysis of transcriptomic data was performed between HNSC and control tissues from TCGA and GEO database. The CD8+ T cell infiltration score was quantified using single-sample gene set enrichment analysis (ssGSEA). Weighted gene co-expression n… Show more

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Cited by 6 publications
(2 citation statements)
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“…ALDH2 is related to immune cells in various tumor microenvironments. In head and neck squamous cell carcinoma, ALDH2 is associated with CD8+ T cell infiltration in the tumor microenvironment 36 . As a biomarker of prostate cancer prognosis, ALDH2 expression is positively associated with B cells, CD8+ T cells, neutrophils, and macrophages 37 .…”
Section: Discussionmentioning
confidence: 99%
“…ALDH2 is related to immune cells in various tumor microenvironments. In head and neck squamous cell carcinoma, ALDH2 is associated with CD8+ T cell infiltration in the tumor microenvironment 36 . As a biomarker of prostate cancer prognosis, ALDH2 expression is positively associated with B cells, CD8+ T cells, neutrophils, and macrophages 37 .…”
Section: Discussionmentioning
confidence: 99%
“…RNA based studies are known with hepatocellular carcinoma [21], colorectal cancer [22], pathway detection [23], prostate tumor [24], and breast cancer [16] etc. RNA expression profile/signature are also used for early diagnosis [25,26]. Early diagnosis is directly linked with development of biomarker signature (i.e., gene set) with population discrimination capacity [27].…”
Section: Introductionmentioning
confidence: 99%