Identifying trajectories of medial joint-space width loss and associated risk factors

Abstract

of alpha angle and horizontal toit externe angle. Table 1 shows a summary of the results. Figure 1 shows the bimodal distribution of alpha angle. Figure 2 shows a scatter plot of alpha angle by side, highlighting both bilateral and unilateral head asphericity. In addition, with an alpha angle cut point of 65 for cam type femoroacetabular impingement (FAI), 31.7% the cohort would be considered to have some degree of FAI, 45.8% of that bilateral. Ă ĂConclusion: Wide variation in hip morphology is present in the normal population. The most interesting of findings were in relation to alpha angle, which showed a bimodal distribution, suggesting a discrete pathological entity, this when combined with its discrete asymmetry suggests and acquired pathology. This is further supported by the normal distribution and symmetry of the other morphological variables. The detailed description of hip morphology in this population cohort has clinical significance in providing a normal reference range for morphological measurement and suggests an acquired process for cam type deformity.

Best performing definition of accelerated knee osteoarthritis: data from the Osteoarthritis Initiative

“…The three JSW-based definitions require a knee to lose more than 0.25 mm/year of medial JSW [Neogi et al 2012], more than 1.05 mm/year of medial JSW [Bartlett et al 2011], or at least 2.00 mm/year of JSW [Hochberg, 2015;Roemer et al 2015]. The implications of using these various definitions remains unclear; however, the prevalence of AKOA based on each definition varies: 3.4% of participants with a comprehensive KL-based definition [Driban et al 2014[Driban et al , 2015a[Driban et al , 2015b[Driban et al , 2016, 10-15% with the lenient KL-based definition (Wesseling et al 2015), 2% with more than 1.05 mm/year of medial JSW [Bartlett et al 2011], and 23% with more than 0.25 mm/year of medial JSW [Neogi et al 2012]. Since no study has examined all of these definitions in one study sample, it remains unclear how the various definitions influence prevalence rates, relate to each other, and influence effect estimates for known risk factors and knee pain.…”

Individuals with incident accelerated knee osteoarthritis have greater pain than those with common knee osteoarthritis progression: data from the Osteoarthritis Initiative

“…It has recently been appreciated that 3 to 17% of people experience accelerated knee osteoarthritis (AKOA), a rapid progression of structural damage that leads to end-stage disease in less than 4 years [1–3]. Individuals who develop AKOA are more likely to be older, overweight, and more likely to experience a recent knee injury than individuals with a slower onset of osteoarthritis or no progression at all [1,3].…”

“…Individuals who develop AKOA are more likely to be older, overweight, and more likely to experience a recent knee injury than individuals with a slower onset of osteoarthritis or no progression at all [1,3]. Despite evidence that individuals with AKOA may be unique at baseline, it is unclear if knee pain, other patient-reported outcomes, and physical performance measures differ between individuals who develop AKOA versus those with a gradual onset that is typically associated with common knee osteoarthritis.…”

Coronal tibial slope is associated with accelerated knee osteoarthritis: data from the Osteoarthritis Initiative

“…Accelerated knee osteoarthritis may be a unique subset of knee osteoarthritis, which develops definite osteophytes and joint space narrowing in less than 4 years (Kellgren-Lawrence [KL] Grade 0–1 to 3–4) [ 1 – 3 ]. Individuals who develop accelerated knee osteoarthritis are often older, overweight, and more likely to have a history of a recent knee injury than those with a slower onset of osteoarthritis or no osteoarthritis at all [ 1 , 3 ]. Furthermore, individuals with accelerated knee osteoarthritis have greater knee pain and disability compared with those with a slower onset of knee osteoarthritis [ 4 ].…”