Objectives
While critical care physicians view obesity as an independent poor prognostic marker, growing evidence suggests that obesity is, instead, associated with improved mortality following ICU admission. However, this prior empirical work may be biased by preferential admission of obese patients to ICUs, and little is known about other patient-centered outcomes following critical illness. We sought to determine whether one-year mortality, health care utilization, and functional outcomes following a severe sepsis hospitalization differ by BMI.
Design
Observational cohort study.
Patients
We analyzed 1,404 severe sepsis hospitalizations (1999ā2005) among Medicare beneficiaries enrolled in the nationally representative Health & Retirement Study, of which 597 (42.5%) were normal weight, 473 (33.7%) were overweight, and 334 (23.8%) were obese or severely obese, as assessed at their survey prior to acute illness. Underweight patients were excluded a priori.
Interventions
None.
Measurements and Main Results
Using Medicare claims, we identified severe sepsis hospitalizations and measured inpatient health care facility use and calculated total and itemized Medicare spending in the year following hospital discharge. Using the National Death Index, we determined mortality. We ascertained pre- and post-morbid functional status from survey data. Patients with greater BMIs experienced higher 1-year mortality compared to non-obese patients, and there was a dose response relationship such that obese (OR=0.59, 95%CI 0.39, 0.88) and severely obese patients (OR=0.46, 95%CI 0.26, 0.80) had the lowest mortality. Total days in a health care facility and Medicare expenditures were greater for obese patients (p<0.01 for both comparisons), but average daily utilization (p=0.44) and Medicare spending were similar (p=0.65) among normal, overweight and obese survivors. Total function limitations following severe sepsis did not differ by BMI category (p=0.64).
Conclusions
Obesity is associated with improved mortality among severe sepsis patients. Due to longer survival, obese sepsis survivors use more health care and result in higher Medicare spending in the year following hospitalization. Median daily health care utilization was similar across BMI categories.