2024
DOI: 10.3390/cancers16193280
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IDH2 Inhibitors Gain a Wildcard Status in the Cancer Therapeutics Competition

Roberto Piva,
Nariman Gharari,
Maria Labrador
et al.

Abstract: The metabolic reprogramming characteristic of cancer cells, including the Warburg effect, has long been recognized as a hallmark of malignancy. This commentary explores three recent investigations focusing on the role of wild-type IDH2 in cancer and immune cell function. The first publication identifies wild-type IDH2 as a crucial factor in the survival of triple-negative breast cancer (TNBC) cells, with its inhibition leading to disrupted energy metabolism, reduced tumor growth, and enhanced apoptosis. The se… Show more

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