Idiopathic and connective tissue disease-associated pulmonary arterial hypertension (PAH): Similarities, differences and the role of autoimmunity

Favoino, Elvira; Prete, Marcella; Liakouli, Vasiliki; Leone, Patrizia; Sisto, Adriana; Navarini, Luca; Vomero, Marta; Ciccia, Francesco; Ruscitti, Piero; Racanelli, Vito; Giacomelli, Roberto; Perosa, Federico

doi:10.1016/j.autrev.2024.103514

Autoimmunity Reviews

2024

DOI: 10.1016/j.autrev.2024.103514

|View full text |Cite

Idiopathic and connective tissue disease-associated pulmonary arterial hypertension (PAH): Similarities, differences and the role of autoimmunity

Elvira Favoino,

Marcella Prete,

Vasiliki Liakouli

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 136 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Sex Dimorphism in Pulmonary Arterial Hypertension Associated With Autoimmune Diseases

Krzyżewska,

Kurakula

2024

ATVB

View full text Add to dashboard Cite

Pulmonary hypertension is a rare, incurable, and progressive disease. Although there is increasing evidence that immune disorders, particularly those associated with connective tissue diseases, are a strong predisposing factor in the development of pulmonary arterial hypertension (PAH), there is currently a lack of knowledge about the detailed molecular mechanisms responsible for this phenomenon. Exploring this topic is crucial because patients with an immune disorder combined with PAH have a worse prognosis and higher mortality compared with patients with other PAH subtypes. Moreover, data recorded worldwide show that the prevalence of PAH in women is 2× to even 4× higher than in men, and the ratio of PAH associated with autoimmune diseases is even higher (9:1). Sexual dimorphism in the pathogenesis of cardiovascular disease was explained for many years by the action of female sex hormones. However, there are increasing reports of interactions between sex hormones and sex chromosomes, and differences in the pathogenesis of cardiovascular disease may be controlled not only by sex hormones but also by sex chromosome pathways that are not dependent on the gonads. This review discusses the role of estrogen and genetic factors including the role of genes located on the X chromosome, as well as the potential protective role of the Y chromosome in sexual dimorphism, which is prominent in the occurrence of PAH associated with autoimmune diseases. Moreover, an overview of animal models that could potentially play a role in further investigating the aforementioned link was also reviewed.

show abstract

Sex Dimorphism in Pulmonary Arterial Hypertension Associated With Autoimmune Diseases

Krzyżewska,

Kurakula

2024

ATVB

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Idiopathic and connective tissue disease-associated pulmonary arterial hypertension (PAH): Similarities, differences and the role of autoimmunity

Cited by 1 publication

References 136 publications

Sex Dimorphism in Pulmonary Arterial Hypertension Associated With Autoimmune Diseases

Sex Dimorphism in Pulmonary Arterial Hypertension Associated With Autoimmune Diseases

Contact Info

Product

Resources

About