Idiopathic and Secondary Mesangiocapillary Glomerulonephritis

Zamurović, D.; Churg, Jacob

doi:10.1159/000183297

Cited by 15 publications

(8 citation statements)

References 18 publications

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“…A variety of glomerular diseases, many with known underlying mechanisms showing similar pathologic changes have been classified under secondary MCGN [10]. As there was no evidence of chronic or recurrent infectious processes, underlying systemic diseases or any other etiologic factors known to cause secondary MCGN, the pathogenesis of renal disease in our cases with Down's syndrome is unclear.…”

Section: Discussionmentioning

confidence: 91%

Mesangiocapillary Glomerulonephritis in Down’s Syndrome

Gupta¹,

Venkataseshan²,

Churg³

1991

Am J Nephrol

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The clinical and pathologic features of progressive renal disease in 4 patients with Down’s syndrome are described. All patients were male, between 20 and 30 years of age at the time of clinical presentation. Three out of 4 had proteinuria, and 2 had hematuria. Serologic tests for hepatitis B virus infection and antinuclear antibodies performed in 2 patients were negative. Examination of renal tissue from biopsy and/or from autopsy revealed mesangiocapillary glomerulonephritis (MCGN), type 1. While an increased incidence of congenital heart disease and acute leukemias has been documented in Down’s syndrome, an association with MCGN has not been reported previously to our knowledge. This probably represents a form of idiopathic MCGN and may be related to the long survival of these individuals.

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Section: Discussionmentioning

confidence: 91%

Mesangiocapillary Glomerulonephritis in Down’s Syndrome

Gupta¹,

Venkataseshan²,

Churg³

1991

Am J Nephrol

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“…In addition, the morphologic changes in types I and III MPGN are not unique to idiopathic MPGN, but can occur with autoimmune diseases, bacterial, protozoal and viral infections, and in neoplastic disorders. [17][18][19][20] The exact incidence of any glomerulonephritis is difficult to establish, however, the high incidence of MPGN in non-industrialized countries 21 could be explained in part by the large number and diversity of infectious diseases in these countries. The histologic pattern of "secondary" MPGN is quite similar to type I, and more so in type III MPGN.…”

Section: Discussionmentioning

confidence: 99%

A Study of Membranoproliferative Glomerulonephritis in Iran

1999

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Background:The aim of this study was to review the morphologic patterns of membranoproliferative glomerulonephritis (MPGN) in 100 Iranian patients using light microscopy (LM) and electron microscopy (EM), and to compare the treatment and outcome in 13 patients with two biopsies. Patients and Methods: A retrospective study of 713 kidney biopsies of Iranian patients received between 1981 to 1994 was carried out. Of the 713 kidney biopsies, MPGN (n=106) and membranous glomerulopathy (n=112) made up the highest numbers of cases. Results: Among 100 MPGN patients, 55 (55%) were MPGN type I, 10 were type II (10%), and 35 type III (35%). Eighty-three (83%) had nephrotic proteinuria, 39 (39%) had hematuria, and 52 (52%) were hypertensive. Complement levels were estimated in 58, with low C3 in 10. The glomerular involvement was irregular, with focal hypercellularity in 47 patients (47%), widely patent capillaries in 50 (50%), arteriosclerosis in 48 (48%), and with hyaline change in 25 (25%). Follow-up data (22-130 months) was available in 61 (61%) patients: 6 (10%) died after 14-56 months, 27 (44%) were on maintenance hemodialysis for 15-110 months, and three received transplants. Thirteen patients had detailed follow-up and a second biopsy after 24-120 months. All 13 presented with edema and nephrotic range proteinuria, with hematuria and hypertension in five and azotemia in four. Seven of the 13 patients received initial steroids, followed by antiplatelet or antihypertensive drugs. Four (type III) patients received antiplatelet and antihypertension drugs, and two (type III) received only antihypertensive drugs. In the first biopsy, glomerular changes by light microscopy were non-uniform in 7 of 10 (70%) type III MPGN cases. Vascular changes were absent or mild in 11, and moderate in two. In the second biopsies, 10 showed decrease in cellularity, with many open capillaries, persistence of deposits by EM in all, and progression of vascular sclerosis in eight, and tubulointerstitial changes in 10. Among the 13, six were clinically stable, another six received dialysis followed by transplant in three, and one had relapses with episodes of cryoglobulinemia. Three patients died. Conclusion: There is a high incidence of MPGN in Iranian patients, with a substantial number of type III MPGN cases. Second biopsies showed decreased cellularity, but increase in chronic tubulointerstitial and vascular cases. Steroids did not appear to benefit the outcome in types I and III MPGN patients compared to patients who received antihypertensive and antiplatelet treatment without steroids.

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“…Membranoproliferative glomerulonephritis has been long recognized in association with hepatitis B infection [21]. Hepatitis C virus has now been linked to both mixed cryoglobulinemia and membranoproliferative glomerulo nephritis [22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Glomerulonephritis, Thrombocytopenia, and Autoimmune Neutropenia Probably Induced by a Virus-Like Illness: Case Report and Review of the Literature

Mackey

Kjellstrand²

1995

Nephron

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We observed a patient who developed severe autoimmune neutropenia, thrombocytopenia, and membranoproliferative glomerulonephritis with severe acute renal failure during the course of an apparent viral illness. Viral inclusion bodies were found on urinary cytopathology and tubular cells in the urine as well as in the renal parenchyma on a renal biopsy. However, all viral cultures and serology were negative or normal. The renal failure improved with rehydration and high-dose intravenous IgG. The neutropenia and thrombocytopenia responded only briefly but were brought into prolonged remission by oral administration of prednisone.

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Idiopathic and Secondary Mesangiocapillary Glomerulonephritis

Cited by 15 publications

References 18 publications

Mesangiocapillary Glomerulonephritis in Down’s Syndrome

Mesangiocapillary Glomerulonephritis in Down’s Syndrome

A Study of Membranoproliferative Glomerulonephritis in Iran

Glomerulonephritis, Thrombocytopenia, and Autoimmune Neutropenia Probably Induced by a Virus-Like Illness: Case Report and Review of the Literature

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Idiopathic and Secondary Mesangiocapillary Glomerulonephritis

Cited by 15 publications

References 18 publications

Mesangiocapillary Glomerulonephritis in Down&rsquo;s Syndrome

Mesangiocapillary Glomerulonephritis in Down&rsquo;s Syndrome

A Study of Membranoproliferative Glomerulonephritis in Iran

Glomerulonephritis, Thrombocytopenia, and Autoimmune Neutropenia Probably Induced by a Virus-Like Illness: Case Report and Review of the Literature

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Mesangiocapillary Glomerulonephritis in Down’s Syndrome

Mesangiocapillary Glomerulonephritis in Down’s Syndrome