Idiopathic Aplastic Anaemia in Children

Killander, A.; Sjölin, Stig

doi:10.1111/j.1651-2227.1969.tb04323.x

Cited by 25 publications

(2 citation statements)

References 11 publications

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“…This finding, assumed to reflect two distinct disease categories, has led to attempts to subclassify patients at the begin of their disease by means of clinical fac tors, initial blood studies, or a combination of both. A rapid onset of disease and the presence of hemor rhagic symptoms is associated with diminished sur vival [4,5], as are low initial counts of neutrophils [4,6,7], platelets [4,6] or reticulocytes [2,4,6,8,9]. In our hands, an initial analysis of numbers of reticulo cytes proved impractical due to considerable day-today fluctuations.…”

Section: Discussionmentioning

confidence: 99%

Aplastic Anemia: Assessment of Myeloid Progenitor Cells in the Bone Marrow and Blood Provides Prognostic Information

Hinterberger¹,

Geißler²,

Fischer³

et al. 1985

Acta Haematol

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15 patients with aplastic anemia were prospectively followed after having measurements of myeloid progenitor cells in bone marrow and blood. Treatment included androgens, low or high dose steroids and standardized supportive care. The median length of survival was 5.8 months. When patients were grouped according to the numbers of myeloid progenitor cells present in their blood and bone marrow, we found that the survival length of aplastic patients with higher progenitor cell numbers was prolonged when compared to that of patients with lower numbers of these cells. The prognostic information obtained from such in vitro cultures was particularly indicative when the patients were grouped according to ‘growth’ and ‘no growth’: the absence of colony-forming myeloid stem cells was associated with survival times significantly shorter than those of patients whose cells maintained their colony-forming capacity. Besides initial numbers of myeloid progenitor cells, only initial numbers of granulocytes were related to survival length. Thus, the measurement of myeloid progenitor cells in bone marrow and blood can be of prognostic value in patients with aplastic anemia.

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Section: Discussionmentioning

confidence: 99%

Aplastic Anemia: Assessment of Myeloid Progenitor Cells in the Bone Marrow and Blood Provides Prognostic Information

Hinterberger¹,

Geißler²,

Fischer³

et al. 1985

Acta Haematol

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“…They have been used in a variety of refractory anaemias with widely varying responses. The most impressive clinical use has been in idiopathic aplastic anaemias of children (Shahidi and Dia-mond, 1961;Killander et al, 1969). It was therefore decided to evaluate androgen therapy in the anaemia of long-term haemodialysis patients in the hope that an overall improvement in haemoglobin levels could be obtained.…”

Section: Introductionmentioning

confidence: 99%

Testosterone Therapy for Anaemia in Maintenance Dialysis

Shaldon¹,

Koch²,

Oppermann³

et al. 1971

BMJ

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Male Sex Hormones, Analogs, and Antagonists

Brueggemeier

2010

Burger's Medicinal Chemistry and Drug Discovery

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The steroid testosterone is the major circulating sex hormone of the male and serves as the prototype for the androgens, the anabolic agents, and androgen antagonists. The endogenous androgens are biosynthesized from cholesterol in various tissues in the body; the majority of the circulating androgens are made in the testes under the stimulation of the gonadotropin luteinizing hormone ( LH ). The reduction of testosterone to dihydrotestosterone is necessary for the androgenic actions of testosterone in many androgen target tissues such as the prostate; the oxidation of testosterone by the enzyme aromatase produces estrogens. The androgenic actions of testosterone and dihydrotestosterone are due to their binding to the androgen receptor, followed by nuclear localization, dimerization of the receptor complex, and binding to a specific DNA sequence. This binding of the homodimer to the androgen response element leads to gene expression, stimulation or repression of the synthesis of new mRNA, and subsequent protein biosynthesis. The synthetic androgens and anabolics were prepared to impart oral activity to the androgen molecule, to separate the androgenic effects of testosterone from its anabolic effects, and to improve upon its biological activities. Novel nonsteroidal androgens, termed selective androgen receptor modulators, were developed to impart agonist activity in selective tissues. Drug preparations are used for the treatment of various androgen‐deficient diseases, for the therapy of diseases characterized by muscle wasting and protein catabolism, for postoperative adjuvant therapy, and for the treatment of certain hormone‐dependent cancers. The two major categories of androgen antagonists are the antiandrogens, which block interactions of androgens with the androgen receptor, and the inhibitors of androgen biosynthesis and metabolism. Such compounds have therapeutic potential in the treatment of acne, virilization in women, hyperplasia and neoplasia of the prostate, and baldness and male contraception.

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Idiopathic Aplastic Anaemia in Children

Cited by 25 publications

References 11 publications

Aplastic Anemia: Assessment of Myeloid Progenitor Cells in the Bone Marrow and Blood Provides Prognostic Information

Aplastic Anemia: Assessment of Myeloid Progenitor Cells in the Bone Marrow and Blood Provides Prognostic Information

Testosterone Therapy for Anaemia in Maintenance Dialysis

Male Sex Hormones, Analogs, and Antagonists

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