Idiopathic bilateral hypertrophic olivary degeneration

Manchikanti, Venkatesh; Chakkalakkoombil, Sunitha Vellathussery; Nair, Pradeep Pankajakshan; Sowkar, Umar Basha

doi:10.1136/bcr-2017-223115

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…5 Previous studies have described both unilateral and bilateral HOD from multiple causes including stroke, cavernous hemangioma rupture, surgical injury, neoplasm, and multiple sclerosis. [6][7][8][9][10] In this review, we intend to elucidate the complex gross anatomy of the rubro-olivary dentate tract (ROD). We then review the imaging anatomy of the ROD and medullary brainstem.…”

Section: Background Informationmentioning

confidence: 99%

Bilateral Hypertrophic Olivary Degeneration Following Brainstem Insult: A Retrospective Review and Examination of Causative Pathology

2021

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Hypertrophic olivary degeneration is a rare condition caused by a lesion in the Guillain-Mollaret triangle which leads to trans-synaptic degeneration resulting in the degenerative hypertrophy of the inferior olivary nucleus. This condition presents clinically with palatal tremor but can also produce ocular myoclonus or cerebellar signs. While any lesion that occurs within the Guillian-Mollaret triangle and results in the deafferentation of the inferior olive can lead to hypertrophic olivary degeneration, the most common etiologies include ischemic and hemorrhagic stroke, vascular malformation, neoplasm, and iatrogenic injury related to surgery. We report a series of 7 patients who presented with this condition bilaterally on MRI imaging, including 1 case which represents the first report of toxoplasmosis leading to the development of bilateral hypertrophic olivary degeneration and only the third reported case, unilateral or bilateral, related to an infectious etiology.

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Section: Background Informationmentioning

confidence: 99%

Bilateral Hypertrophic Olivary Degeneration Following Brainstem Insult: A Retrospective Review and Examination of Causative Pathology

2021

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“…• Dentatorubral fibers that arise from the contralateral dentate nucleus and pass through the superior cerebellar peduncle and decussate within the midbrain to reach the opposite red nucleus. • The ipsilateral central tegmental or rubro-olivary tract that descends from the red nucleus to the inferior olivary nucleus 7,8 (Figure 1).…”

Section: Hypertrophic Olivary Degeneration Caused By a Central Tegmental Tract Lesionmentioning

confidence: 99%

Transaxonal degenerations of cerebellar connections: the value of anatomical knowledge

Raeder

Reis

Campos

et al. 2020

Arq. Neuro-Psiquiatr.

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Transaxonal degenerations result from neuronal death or the interruption of synaptic connections among neuronal structures. These degenerations are not common but may be recognized by conventional magnetic resonance imaging. Objective: The learning objectives of this review include recognition of the imaging characteristics of transaxonal degenerations involving cerebellar connections, the identification of potential encephalic lesions that can lead to these degenerations and correlation of the clinical manifestations with imaging findings that reflect this involvement. Methods: In this report, we review the neuroanatomical knowledge that provides a basis for identifying potential lesions that can result in these degenerations involving cerebellar structures. Results: Hypertrophic olivary degeneration results from an injury that interrupts any of the components of the Guillain-Mollaret triangle. In this work, we describe cases of lesions in the dentate nucleus and central tegmental tract. The crossed cerebellar diaschisis presents specific imaging findings and clinical correlations associated with its acute and chronic phases. The Wallerian degeneration of the middle cerebellar peduncle is illustrated by fiber injury of the pontine cerebellar tracts. A T2-hyperintensity in the dentate nucleus due to a thalamic acute lesion (in ventral lateral nuclei) is also described. Each condition described here is documented by MRI images and is accompanied by teaching points and an anatomical review of the pathways involved. Conclusion: Neurologists and radiologists need to become familiar with the diagnosis of these conditions since their presentations are peculiar and often subtle, and can easily be misdiagnosed as ischemic events, degenerative disease, demyelinating disease or even tumors.

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The first case report of spinocerebellar ataxia type-40 in India: novel phenotypic and radiological (bilateral olivary degeneration) features and a comprehensive review of this remarkable radiological sign

et al. 2022

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Idiopathic bilateral hypertrophic olivary degeneration

Cited by 3 publications

References 3 publications

Bilateral Hypertrophic Olivary Degeneration Following Brainstem Insult: A Retrospective Review and Examination of Causative Pathology

Bilateral Hypertrophic Olivary Degeneration Following Brainstem Insult: A Retrospective Review and Examination of Causative Pathology

Transaxonal degenerations of cerebellar connections: the value of anatomical knowledge

The first case report of spinocerebellar ataxia type-40 in India: novel phenotypic and radiological (bilateral olivary degeneration) features and a comprehensive review of this remarkable radiological sign

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