Idiopathic bullous eosinophilic cellulitis (Wells syndrome) responsive to topical tacrolimus and antihistamine combination

Verma, Prashant; Singal, Archana; Sharma, Sonal

doi:10.4103/0378-6323.95468

Cited by 10 publications

(7 citation statements)

References 5 publications

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“…Tacrolimus as an immunosuppressant is frequently used for the therapy of inflammatory diseases. It has the ability of down‐regulating the IgE receptor on Langerhans cells, being important for the formation of flame figures . A patient with Wells syndrome was treated with 10 mg cetirizine twice a day for 2 weeks continuing with 10 mg/day for another 4 weeks.…”

Section: Resultsmentioning

confidence: 99%

“…Although the lesions showed a complete remission, they reoccurred after 9 weeks. That was why topical 0.1% tacrolimus was added to the treatment regimen and the lesions resolved after 2 weeks without any relapse …”

Section: Resultsmentioning

confidence: 99%

“…It has the ability of down-regulating the IgE receptor on Langerhans cells, being important for the formation of flame figures. 31 A patient with Wells syndrome was treated with 10 mg cetirizine twice a day for 2 weeks continuing with 10 mg/day for another 4 weeks. Although the lesions showed a complete remission, they reoccurred after 9 weeks.…”

Section: Oral/topical Tacrolimusmentioning

confidence: 99%

“…That was why topical 0.1% tacrolimus was added to the treatment regimen and the lesions resolved after 2 weeks without any relapse. 31 Apart from local therapy, oral tacrolimus in a dose of 1 mg/ day may be helpful in therapy-refractory eosinophilic cellulitis. 32 Nevertheless, it has to be taken into consideration that, in the above report, 5 mg prednisolone was taken accompanying to the tacrolimus therapy, so the effect of tracrolimus itself is hard to estimate.…”

Section: Oral/topical Tacrolimusmentioning

confidence: 99%

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Treatment of eosinophilic cellulitis (Wells syndrome) – a systematic review

Räßler

Lukács

Elsner

2016

Acad Dermatol Venereol

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Eosinophilic cellulitis (Wells syndrome) is a rare inflammatory skin disease defined by erythematous, tender, sometimes urticarial plaques, possibly with vesicles and bullae, and granulomatous eosinophilic infiltrates in the dermis. Usually the disease has a benign course with spontaneous remission within a few weeks. Nevertheless, recurrences are quite frequent and may occur for several years. The objective of this study was to review the so far reported treatment options for Wells syndrome in a systematic manner. This systematic review is based on a search on Medline, Embase and Cochrane Central Register for English and German articles from 1970 to 2015. Advices on the treatment of Wells syndrome are limited predominately to case reports or to small case series. There are no randomized controlled trials, and control groups are missing. A variety of treatment options for Wells syndrome were reported including topical and systemic corticosteroids, antihistamines, cyclosporine, dapsone, azathioprine, griseofulvin, doxycycline, minocycline, antimalarial medications, oral tacrolimus/topical tacrolimus, sulfasalazine, interferon alpha and gamma, TNF alpha inhibitors, colchicine and PUVA therapy. As well-designed, randomized controlled trials are missing, no guidelines for the treatment of this disease can be given. Due to the small number of patients and the frequent misdiagnosis of this clinical entity, the aim of this systematic overview is to call attention to this rare condition and to help clinicians to diagnose and treat Wells syndrome effectively. Due to the good prognosis and tendency to resolve, systemic treatment should be limited to cases resistant to local therapy or with widespread lesions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Oral/topical Tacrolimusmentioning

confidence: 99%

Section: Oral/topical Tacrolimusmentioning

confidence: 99%

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Treatment of eosinophilic cellulitis (Wells syndrome) – a systematic review

Räßler

Lukács

Elsner

2016

Acad Dermatol Venereol

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“…Имеются сообщения о хорошем эффекте адалимумаба, циклоспорина [31,32]. В качестве наружных препаратов используют наружные и внутриочаговые инъекции кортикостероидов, ингибиторы кальциневрина [30,33].…”

unclassified

Eosinophilic cellulitis (Wells syndrome): diagnostic features

Haliulin¹,

Павлов²,

Chan³

et al. 2017

Klin. dermatol. venerol.

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Синдром Уэллса (эозинофильный целлюлит Уэллса) является редким заболеванием неизвестной этиологии. Во всем мире зарегистрировано около 80 случаев. Высыпания при синдроме Уэллса похожи на целлюлит, однако инфекции не обнаруживается. Синдром Уэллса может развиться вследствие приема медикаментов, наличия различных инфекций и, вероятно, при наличии злокачественных новообразований. Несмотря на то что синдром Уэллса является спорадическим заболеванием, имеются сведения о семейных случаях. Диагноз синдрома Уэллса устанавливается на основании данных гистологического исследования. Прогноз благоприятный: кожный процесс регрессирует в течение нескольких недель или месяцев, в большинстве случаев бесследно.

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