Idiopathic chondrolysis of the hip. Report of two cases

Wenger,; Mickelson,; Ponseti, Ignacio V.

doi:10.2106/00004623-197557020-00024

Cited by 31 publications

(14 citation statements)

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“…41 Our findings in C3 and C4 complement and immunoglobulins serum levels determination coincide in some aspects with those of the literature, [41][42][43] and warrant the supposition of an autoimmune response playing a part in the process of the articular cartilage lesion.…”

Section: Discussionsupporting

confidence: 87%

Effect of oral diacerein (DAR) in an experimental hip chondrolysis model

Kitadai

Takahashi

Straus

et al. 2006

Journal Orthopaedic Research

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We aimed to reproduce the articular cartilage structural changes in a joint exposed to a metallic implant as in the adolescent pinned hip with persistent joint penetration and secondly, to test the effect of an interleukin inhibitor, diacerein (DAR) in the ensuing articular cartilage lesion. Twenty immature beagles were submitted to a surgical K-wire implantation in the hip with the material left in the joint space for 6 months. Twelve animals were sacrificed for histological and biochemical tests. Eight animals were sacrificed at 10 months (half of them treated with DAR) and analyzed by scanning electron microscopy (SEM) and biochemistry of the articular cartilage. Preoperative and monthly C3 and C4 complement and immunoglobulins serum levels were determined. The histological and the electrophoretic profile changes were significative at 6 months. At 10 months the migration profile (CaCl 2 ) recovered to normal levels in the operated hip and the SEM scores for the acetabulum were similar to the non operated control hip after treatment. The serum level of IgA was elevated at the 4th and 6th month postoperatively. The persistence of a metallic implant resulted in degenerative changes parallel to that described for hip chondrolysis as a complication of in-situ pinning; and the cartilage lesion improved with DAR treatment. ß

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Section: Discussionsupporting

confidence: 87%

Effect of oral diacerein (DAR) in an experimental hip chondrolysis model

Kitadai

Takahashi

Straus

et al. 2006

Journal Orthopaedic Research

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“…A few papers suggest a role of immunologic disorders in the pathogenesis of chondrolysis (Golding 1973, Duncan 1975, Mankin 1975, Wenger 1975. Golding (1973) suggested that the condition might be due to the formation of immunocomplexes in the superficial layers of the articular cartilage, causing cartilage destruction and synovitis.…”

Section: Discussionmentioning

confidence: 99%

“…It has also been reported after trauma (Pellici 1979) and Bleck (1983), infection (Wenger 1975), and prolonged immobilization (Heppenstall 1974). Duncan (1975Duncan ( , 1979 presented cases of chondrolysis of the hip in children in whom no specific cause could be found.…”

Section: Idiopathic Chondrolysis Of the Hip A Distinct Clinical Entitmentioning

confidence: 92%

Idiopathic chondrolysis of the hip A distinct clinical entity?

Keessen

Kuis

1989

Acta Orthopaedica Scandinavica

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“…Idiopathic chondrolysis typically occurs in black female adolescents. There is still no consensus regarding etiology [4][5][6][7][8][9][10][11][12].…”

Section: Etiologymentioning

confidence: 99%