Idiopathic chylous ascites in a patient with HIV infection: response to total parenteral nutrition and octreotide therapy

Nunes, Gonçalo; Fonseca, Cristina; Barosa, Rita; Patita, Marta; Gomes, André; Botas, J; Coelho, Hélder; Brito, María José; Fonseca, Jorge

doi:10.1007/s12328-018-0832-x

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…A definitive treatment in view of future cancer risk and debilitating morbidity is surgical, subtotal, or total gastrectomy [ 2 , 15 ]. Octreotide at a dose of 100 to 600 micrograms daily has been shown to be beneficial in case reports as it acts by modulating the TGF-alpha-EGFR pathway, which is the underlying pathogenic mechanism [ 16 ]. In recent cases, cetuximab and monoclonal antibodies to EGFR have been successfully used to treat MD [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

The Great Mimicker of Gastric Cancer: A Case Report of Ménétrier's Disease

Roy,

Neogi,

Chaturvedi

et al. 2024

Cureus

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This is the case of a 52-year-old Indian lady who presented with hematemesis, severe anemia, and an abdominal lump in cardiac failure. On radiographic evaluation, the lesion appeared to be gross circumferential asymmetric proximal gastric wall thickening, with suspicion of gastric lymphoma or tubercular hypertrophic gastritis. After stabilization with multiple transfusions, she underwent proximal D2 gastrectomy with esophago-gastric anastomosis and a total splenectomy. Grossly, the gastric rugae appeared to be hypertrophied and firm. No growth was identified grossly; however, necrotic areas were identified at the distal end. Microscopic examination of multiple sections studied showed significant foveolar hyperplasia, tortuous glands, and a few cystically dilated foveolar glands, which were limited up to the muscle layer. Mild serosal congestion was seen. No atypia or invasion was seen. An impression to consider is the possibility of Ménétrier’s disease (MD). MD is an acquired protein-losing enteropathy with giant gastric rugal folds, decreased acid secretion, and increased gastric mucous production. Radiographically, endoscopically, and grossly, the condition can be confused with malignant lymphoma or carcinoma. It is difficult to diagnose, and histopathological confirmation of the resected specimen is needed for a definitive diagnosis. Our intention in presenting this case is to emphasize that MD can present as massive hematemesis and should be considered in a differential diagnosis. Surgical treatment by total or partial gastrectomy is recommended for cases with persistent, debilitating symptoms or a risk of cancer.

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Section: Discussionmentioning

confidence: 99%

The Great Mimicker of Gastric Cancer: A Case Report of Ménétrier's Disease

Roy,

Neogi,

Chaturvedi

et al. 2024

Cureus

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“…Octreotide has the potential to affect the TGF-α-EGFR pathway, which can be held liable for the proliferation of gastric mucosa [2,16].…”

Section: Treatmentmentioning

confidence: 99%

“…The medication attaches to the EGF receptor, which diminishes the formation of TGF-α. Its consumption has prevented gastrectomy and improved patient's quality of life [2,16]. Surgical treatment is an option for selected cases of Menetrier's disease, specifically for patients experiencing intractable pain, symptomatic and remarkable hypoalbuminemia, chronic hemorrhage, obstruction of the gastrointestinal tract, and when gastric cancer cannot be ruled out.…”

Section: Treatmentmentioning

confidence: 99%

Menetrier's disease - press review and summary of current knowledge

Markowiak,

Wardęszkiewicz,

Jabłońska

et al. 2024

J Educ Health Sport

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Introduction Menetrier's Disease is a rare and mysterious stomach disorder characterised by giant gastric folds, excessive mucus production, and protein loss. This comprehensive research article examines Menetrier's Disease, focusing on its clinical features, diagnosis, and available treatment options. The article aims to provide a complete understanding of Menetrier's Disease, fill the knowledge gap, and encourage improved clinical management. Description of the State of Knowledge Menetrier's Disease is a rare condition, and its cause is still unknown, though it may be linked to previous viral and bacterial infections and increased expression of transforming growth factor-alpha (TGF-α). Diagnosis can be established by endoscopic examination and histological analysis of material from a full-thickness mucosal biopsy. Treatment options are limited and concentrated on symptom relief, while the outcome of the therapy may vary. Summary Menetrier's Disease presents significant difficulties in both diagnosis and treatment. This review outlines the clinical features, classification, diagnostic approaches, available treatment options, and prognosis for healthcare professionals and researchers seeking to understand this disease better. Better understanding of Menetrier's Disease is crucial to improve patient care and explore new, potential therapeutic avenues.

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“…Most previous studies are case reports that report the use of antibiotics, 128 glucocorticoids, 129 and acid‐suppressants, 130 etc. A previous study has indicated that long‐acting somatostatin may be effective for the treatment of Ménétrier's disease, 131 and that hypoalbuminemia and anemia should be corrected concurrently. The treatment of eosinophilic gastritis requires an investigation into the potential allergic factors and elimination of allergens, although some patients also require steroid therapy 132 .…”

Section: Clinical Issues and Statementsmentioning

confidence: 99%

Guidelines for diagnosis and treatment of chronic gastritis inChina(2022,Shanghai)

Fang

2023

J of Digest Diseases

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Chronic gastritis is a commonly seen disease; clinicians have always attached to the importance of understanding its etiology and clinical manifestations, standardizing its diagnosis and treatment, and preventing its progression to cancers. Based on the consensus opinions on the diagnosis and treatment of chronic gastritis in the past three editions, and referring to the international consensuses and guidelines on the management of precancerous lesions of gastric mucosa, it is of clinical value and feasibility to formulate the guidelines for the diagnosis and treatment of chronic gastritis in line with China's national conditions. This guideline was initiated by the Chinese Society of Gastroenterology, with major members of the Cancer Collaboration Group of Chinese Society of Gastroenterology serving as the convenors and authors. Based on the internationally accepted principles and methods of guideline development and the extensive collection of opinions from gastroenterologists and physicians, 53 evidence-based recommendations are given for nine major clinical problems related to chronic gastritis, aiming to improve the diagnosis, treatment, and management of chronic gastritis.

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Idiopathic chylous ascites in a patient with HIV infection: response to total parenteral nutrition and octreotide therapy

Cited by 5 publications

References 10 publications

The Great Mimicker of Gastric Cancer: A Case Report of Ménétrier's Disease

The Great Mimicker of Gastric Cancer: A Case Report of Ménétrier's Disease

Menetrier's disease - press review and summary of current knowledge

Guidelines for diagnosis and treatment of chronic gastritis inChina(2022,Shanghai)

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