Idiopathic Facial Aseptic Granuloma

Idiopathic Facial Aseptic Granuloma: Review of an Evolving Clinical Entity

“…Clinically, subcutaneous facial nodules often provoke a variety of etiologic considerations. Differential diagnosis of IFAG often includes pilomatricomas; dermoid or epidermoid cysts; chalazions; pyogenic granulomas; Spitz nevi; xanthogranulomas; bacterial (impetigo, furuncles), parasitic (leishmaniasis), mycobacterial (treponematosis, bartonellosis), or fungal infections (sporotrichosis); and vascular malformations or hemangiomas . Many clinically similar cases have been reported as infantile nodulocystic acne .…”

Idiopathic Facial Aseptic Granuloma in a 13-Year-Old Boy Dramatically Improved with Oral Doxycycline and Topical Metronidazole: Evidence for a Link with Childhood Rosacea

“…There is no predisposing factor, no family history, and no evidence for a microbial cause [2]. The differential diagnosis of IFAG includes benign tumors, such as pilomatricomas, dermoid or epidermoid cysts, chalazions; bacterial, mycobacterial, fungal or parasitic infections; pyogenic granulomas; Spitz nevi; xanthogranulomas, and vascular malformations or hemangiomas [1, 2, 5]. The pathogenesis of IFAG is still unclear, but it is likely to be associated with granulomatous rosacea in childhood [6].…”

Nodules on the Cheek of a 6‐Year‐Old Girl

“…There are no identifiable associated factors, such as a positive family history or distinctive accompanying clinical findings . Most cases report a solitary lesion , but several children have presented with multiple nodules , with some resolving as others appear .…”

“…Histologic analysis often shows chronic dermal granulomatous inflammation composed of lymphocytes, histiocytes, neutrophils, at times plasma cells or eosinophils, and numerous foreign body–type giant cells . The infiltrate may be centered around a hair follicle or contain a concomitant perifolliculitis .…”