Idiopathic Fibrosis of the Tunica Muscularis of the Large Intestine in Five Horses with Colic

Mair, T. S.; Sherlock, C. E.; Fews, D.; Harley, Ross; Pearson, G. R.

doi:10.1016/j.jcpa.2016.01.001

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…We first confirmed the relevance of collagen to MCs by staining collagen with Van Gieson's reagent. As expected, collagen is widespread throughout the tissue, as evidenced by the red staining (Figure 1A) [31]. Brain MCs, marked by tryptase, are also present in the brain, embedded in collagen fibers alongside neurons (PGP9.5 positive) (Figure 1B).…”

Section: Mcs Are Present In Mouse Brain Surrounded By Collagen-rich E...supporting

confidence: 69%

Amyloid Beta Peptides Lead to Mast Cell Activation in a Novel 3D Hydrogel Model

Liu

Zeng

et al. 2023

IJMS

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Alzheimer’s disease (AD) is a prevalent neurodegenerative disease and the world’s primary cause of dementia among the elderly population. The aggregation of toxic amyloid-beta (Aβ) is one of the main pathological hallmarks of the AD brain. Recently, neuroinflammation has been recognized as one of the major features of AD, which involves a network of interactions between immune cells. The mast cell (MC) is an innate immune cell type known to serve as a first responder to pathological changes and crosstalk with microglia and neurons. Although an increased number of mast cells were found near the sites of Aβ deposition, how mast cells are activated in AD is not clear. We developed a 3D culture system to culture MCs and investigated the activation of MCs by Aβ peptides. Because collagen I is the major component of extracellular matrix (ECM) in the brain, we encapsulated human LADR MCs in gels formed by collagen I. We found that 3D-cultured MCs survived and proliferated at the same level as MCs in suspension. Additionally, they can be induced to secrete inflammatory cytokines as well as MC proteases tryptase and chymase by typical MC activators interleukin 33 (IL-33) and IgE/anti-IgE. Culturing with peptides Aβ1-42, Aβ1-40, and Aβ25-35 caused MCs to secrete inflammatory mediators, with Aβ1-42 inducing the maximum level of activation. These data indicate that MCs respond to amyloid deposition to elicit inflammatory responses and demonstrate the validity of collagen gel as a model system to investigate MCs in a 3D environment to understand neuroinflammation in AD.

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Section: Mcs Are Present In Mouse Brain Surrounded By Collagen-rich E...supporting

confidence: 69%

Amyloid Beta Peptides Lead to Mast Cell Activation in a Novel 3D Hydrogel Model

Liu

Zeng

et al. 2023

IJMS

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“…In horses, main proliferative diseases causing CIBD are granulomatous enteritis, idiopathic eosinophilic enterocolitis, multi systemic eosinophilic epitheliotropic disease (MEED) and lymphocytic-plasmacytic enterocolitis [5]. In this paper, we report a case of Lymphocytic-Plasmacytic Enteritis (LPE) in an elderly horse, presenting longlasting severe cachexia and recurrent colic episodes [6].…”

Section: Introductionmentioning

confidence: 99%

Lymphocytic-Plasmacytic Enteritis as a Cause of Long-Lasting Weight Loss and Recurrent Colic in an Elderly Horse

Barros¹,

Oliveira²,

Campos

et al. 2021

BJSTR

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Lymphocytic-Plasmacytic Enteritis (LPE) is an uncommon cause of chronic inflammatory bowel disease in horses. The proliferative inflammatory cell infiltrate results in diffuse mucosal inflammation and impaired nutrients absorption, leading to chronic weight loss, recurrent abdominal pain and hypoproteinemia. This article reports the case of a 25-year-old horse with LPE causing long-lasting severe cachexia and recurrent colic episodes. A positive response to diet changes and medical treatment with corticosteroids was observed during a short period of time. However, relapse of recurrent colic episodes refractory to medical treatment determined the euthanasia of the horse.

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Investigations of Chronic and Recurrent Colic

White

2017

The Equine Acute Abdomen

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Idiopathic Fibrosis of the Tunica Muscularis of the Large Intestine in Five Horses with Colic

Cited by 5 publications

References 23 publications

Amyloid Beta Peptides Lead to Mast Cell Activation in a Novel 3D Hydrogel Model

Amyloid Beta Peptides Lead to Mast Cell Activation in a Novel 3D Hydrogel Model

Lymphocytic-Plasmacytic Enteritis as a Cause of Long-Lasting Weight Loss and Recurrent Colic in an Elderly Horse

Investigations of Chronic and Recurrent Colic

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