Idiopathic Granulomatous Mastitis: A Heterogeneous Disease with Variable Clinical Presentation

Baslaim, Muna M.; Khayat, Hind A.; Al-Amoudi, Shefaa A

doi:10.1007/s00268-007-9116-1

Cited by 194 publications

(187 citation statements)

References 19 publications

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“…Due to histological similarities between the diseases, the differential diagnosis of granulomatous mastitis also includes tuberculosis, sarcoidosis, Wegener's granulomatosis, fungal infection and aseptic abscesses syndrome (8). Aseptic abscesses syndrome, a clinicopathological entity first described in 1995, is characterized by recurrent manifestations of abscess-like areas that respond to corticosteroid therapy but not to antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Granulomatous Mastitis Complicated by Arthralgia and Erythema Nodosum Successfully Treated with Prednisolone and Methotrexate

Nakamura

Yoshioka²,

Miyashita

et al. 2012

Intern. Med.

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A 23-year-old woman was admitted with complaints of swelling and pain in the left breast, fever, polyarthralgia and erythema nodosum. A fine-needle biopsy of the mass in the left breast revealed non-caseous granulomatous lobulitis. A diagnosis of granulomatous mastitis was thus made. The administration of prednisolone 40 mg/day resulted in the resolution of the patient's symptoms, and the breast mass thereafter decreased in size. The mass relapsed during the subsequent prednisolone taper. Additional therapy with methotrexate resulted in complete remission. Granulomatous mastitis should therefore be included in the differential diagnosis of polyarthralgia.

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Section: Discussionmentioning

confidence: 99%

Granulomatous Mastitis Complicated by Arthralgia and Erythema Nodosum Successfully Treated with Prednisolone and Methotrexate

Nakamura

Yoshioka²,

Miyashita

et al. 2012

Intern. Med.

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“…The higher incidence of IGM during the postpartum and lactation periods and that among women using oral contraceptives draws attention to hormonal factors. Approximately onethird (33%) of all IGM patients have reported the use of oral contraceptives and cases not related to pregnancy (8,9). One of our cases reported a history of use of oral contraceptives.…”

Section: Discussionmentioning

confidence: 88%

The effect of corticosteroid treatment on bilateral idiopathic granulomatous mastitis

2017

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Idiopathic granulomatous mastitis (IGM) is the commonly encountered form of granulomatous mastitis that may result into repetitive infections and/or abscess formation. Mastitis may develop secondary to a systemic disorder such as tuberculosis, diabetes mellitus, or rheumatoid arthritis, or it may develop as an idiopathic disorder. Idiopathic granulomatous mastitis is the most frequent form of all granulomatous diseases affecting the breast. This disorder frequently presents as painful and fast-growing mass in the breast. Biopsy is required to confirm diagnosis. Surgical excision and immunosuppressive treatment with corticosteroids are employed for therapeutic management. Here we present 3 female cases of bilateral IGM who were followed up and treated successfully with 1 mg/kg/day prednisolone.

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“…La mastitis granulomatosa lobular o idiopática (MGI), una enfermedad benigna de etiología no definida, afecta también a mujeres jóvenes en edad reproductiva, presenta compromiso unilateral predominante y se manifiesta como un nódulo o absceso con retracción del pezón, ulceración, fistulización y síntomas sistémicos infrecuentes. No obstante, este diagnóstico amerita además de características anatomo-patológicas típicas, el descarte de otras causas de mastitis granulomatosa (20)(21)(22)(23)(24)(25).…”

Section: Discussionunclassified

Características clínicas y anatomo-patológicas de las pacientes que ingresaron al Programa de Control de Tuberculosis con diagnóstico de tuberculosis de mama

Tafur¹,

Cáceres²,

Accinelli³

2014

Rev Med Hered

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Objetivo: Describir las características clínicas y anatomo-patológicas de pacientes que ingresaron con diagnóstico de TB de mama al Programa de control de Tuberculosis (PCT) de un hospital general. Material y métodos: Se incluyeron los casos registrados en el PCT como TB de mama en cuyo informe anatomo-patológico figuraba inflamación crónica granulomatosa. Se revisaron las historias clínicas y revaluaron las biopsias de mama. Resultados: Se incluyeron 69 mujeres con edad promedio 35,79 ± 7,94 años. Las manifestaciones más frecuentes fueron presencia de nódulo (89,86%), dolor (89,86%) y signos inflamatorios (40,58%). La revaluación de la biopsia mostró granulomas de tipo supurado, con células gigantes multinucleadas tipo Langhans y cuerpo extraño, sin necrosis caseosa, localizados a nivel de la unidad ducto lobular (UDL) y extra-UDL en 85,51 % de los casos. Solo en 3 casos se observó bacilos ácido alcohol resistente en la secreción o tejido de mama. Todos los casos recibieron tratamiento antituberculoso. Treinta y ocho casos tuvieron seguimiento, de ellos 73,68% presentó persistencia o recurrencia al menos un mes después del inicio de tratamiento antituberculoso. Conclusiones: Todos los casos del estudio fueron mujeres, la mayoría presentaron nódulo, dolor o signos de inflamación en mama, sin síntomas o signos sistémicos y con presencia de granulomas supurados, sin necrosis caseosa. A pesar de recibir tratamiento antituberculoso en todos los casos, cerca del 75% con seguimiento de al menos un mes presentaron persistencia o recurrencia clínica.

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Idiopathic Granulomatous Mastitis: A Heterogeneous Disease with Variable Clinical Presentation

Abstract: Management of IGM cases needs to be tailored according to the clinical presentation. Precise radiologic and pathologic data interpretation by a multidisciplinary breast team will facilitate diagnosis and minimize unnecessary intervention.

Cited by 194 publications

References 19 publications

Granulomatous Mastitis Complicated by Arthralgia and Erythema Nodosum Successfully Treated with Prednisolone and Methotrexate

Granulomatous Mastitis Complicated by Arthralgia and Erythema Nodosum Successfully Treated with Prednisolone and Methotrexate

The effect of corticosteroid treatment on bilateral idiopathic granulomatous mastitis

Características clínicas y anatomo-patológicas de las pacientes que ingresaron al Programa de Control de Tuberculosis con diagnóstico de tuberculosis de mama

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