“…It is therefore not surprising that a variety of diffuse damage to the basal ganglia as a whole can be associated with psychotic presentations in 13-30 years old individuals (Table 2, Supplementary Shirahama et al 2010;Rizvi et al 2018;Otheman et al 2011;Lu 2014). In other metabolic disorders such as adult-onset cobalamin C deficiency, which presented with severe paranoid delusions, brain imaging showed extensive basal ganglia involvement as well as diffuse periventricular and dorso-spinal white matter changes (Higashimoto et al 2020).…”