Idiopathic inflammatory myopathies evaluated by near-infrared spectroscopy

Abstract

NIRS differentiated samples of DM and IBM patients from controls, but it could not distinguish PM patients from a sample of healthy subjects.

Near-Infrared Spectroscopy for Monitoring Sternocleidomastoid Muscular Oxygenation during Isometric Flexion for Patients with Mild Nonspecific Neck Pain: A Pilot Study

“…A hyperbolic tangent equation (tanh) was applied to fit the oxygen saturation curves (Y) as a function of time (t) during the contraction and recovery periods to constitute muscular oxygenation kinetics [43] (Figure 2):…”

“…Subsequently, both changes in the oxygenated and deoxygenated hemoglobin concentration could be further deduced from changes in the light intensity through algorithmic transformation governed by the modified Beer-Lambert law. Recent evidences have shown the potential of NIRS in various medical applications, including functional analysis of the brain and continuous monitoring of changes in local muscular oxygenation [34][35][36][37][38][39][40][41][42][43][44][45]. For example, functional NIRS has been used to monitor the time course of oxygenated/deoxygenated hemoglobin signal to estimate regional neural activity of the brain [36] and even could serve as an auxiliary diagnostic apparatus for distinguishing unipolar depression from schizophrenia and bipolar depression [42].…”

“…For example, functional NIRS has been used to monitor the time course of oxygenated/deoxygenated hemoglobin signal to estimate regional neural activity of the brain [36] and even could serve as an auxiliary diagnostic apparatus for distinguishing unipolar depression from schizophrenia and bipolar depression [42]. Similarly, the clinical applicability of NIRS for noninvasive evaluating of deconditioning and reconditioning of skeletal muscle oxidative functions has been emphasized [40], showing slower rates of reoxygenation of lower limb after exercise in patients with peripheral vessel disease [43], respiratory muscle hypoperfusion combined with the greater work of breathing in patients with congestive heart failure [44], functional restoration of muscle oxidative metabolism after renal transplantation [45] as well as regional heterogeneity in the distribution of blood flow and oxygen consumption in exercising muscle in patients with chronic obstructive pulmonary disease [38,39].…”

“…Because of the capability of NIRS for offering non-invasive monitoring of tissue oxygenation in a wide range of clinical scenarios, alternative potential modulatory mechanisms from a muscular oxidative metabolism viewpoint for neck-related neuromuscular conditions have also been considered [36][37][38][39][40][41][42][43][44][45][46][47][48][49]. Existing observation noted that muscular oxygen saturation levels in the trapezius descendens muscles were different between female workers with trapezius myalgia and healthy controls [49].…”

“…However, a lack of studies that characterize the properties of muscular oxygenation for the neck flexor muscles in neck pain patients contributes to the lack of clarity regarding the pathogenic mechanisms underlying neck pain. Since there is merit in non-invasively monitoring muscular oxidative metabolism for NIRS in various clinical conditions [34][35][36][37][38][39][40][41][43][44][45], the present study mainly aimed at evaluating the clinical potential for characterizing the modulatory strategies of sternocleidomastoid muscular oxygenation by means of NIRS in patients with mild nonspecific neck pain. Further, we hypothesized either adaptive manipulations or pathological responses of oxidative metabolism capacity of sternocleidomastoid muscles in nonspecific neck patients with mild disability.…”