Idiopathic intracranial hypertension in Dubai: nature and prognosis

Mezaal, Mohammed Abdulelah; Saadah, Mohammed Ahmed

doi:10.1111/j.1600-0404.2005.00487.x

Cited by 18 publications

(19 citation statements)

References 23 publications

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“…21 and Sadaah et al reported on 50 IIH patients from Dubai (UAE) and again obesity was the most commonly associated risk factor. 10 Two studies conducted in Israel published in 2001 and 2014 by the same authors showed an increased percentage of obesity of 57.2% and 83.4%, respectively, as a major risk factor for IIH. 19,20 The pathophysiological mechanism of obesity in IIH remains unclear.…”

Section: Role Of Obesity On Iihmentioning

confidence: 97%

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Idiopathic intracranial hypertension in the Middle East: A growing concern

Almarzouqi

Morgan

Lee

2015

Saudi Journal of Ophthalmology

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Idiopathic Intracranial Hypertension (IIH) is a disorder of increased intracranial pressure without any identifiable etiology. It is defined by elevated intracranial pressure (ICP) with normal neuroimaging and normal cerebrospinal fluid (CSF) contents. IIH typically affects young obese women and produces symptoms and signs related to high ICP. Headache and blurred vision are the most common symptoms, and papilledema is the major clinical sign. In this review we examine the epidemiology and demographic features of IIH in Middle Eastern countries and compare and contrast them with the published IIH literature from Western countries. The incidence of IIH in several Middle East countries has been estimated at 2.02-2.2/100,000 in the general population, which is higher than the Western rate. Obesity is a major risk factor globally and it is associated with an increased risk of severe vision loss due to IIH. There has been an increase in obesity prevalence in the Middle East countries mainly affecting the Gulf Council Countries (GCC), which parallels increased industrial development. This rise may be contributing to the increasing incidence of IIH in these countries. Other risk factors may also be contributing to IIH in Middle East countries and the differences and similarities to Western IIH merit further study.

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Section: Role Of Obesity On Iihmentioning

confidence: 97%

“…6 In contrast, obesity is not as significant of a risk factor in men as it has been reported by available published studies in GCC but the study numbers are limited. 10,14 …”

Section: Role Of Obesity On Iihmentioning

confidence: 98%

Idiopathic intracranial hypertension in the Middle East: A growing concern

Almarzouqi

Morgan

Lee

2015

Saudi Journal of Ophthalmology

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“…Emerging evidence is showing that an increased TLPD is important in the pathogenesis of glaucoma [2][3][4][5][6], whereas papilledema and anterior disk movement occurs with a reduction or reversal of the TLPD [8,9]. Traditionally, glaucoma pathogenesis has been ascribed to elevated IOP with little regard for CSFp, while diseases of elevated CSFp like IIH have paid little attention to IOP.…”

Section: The Hypothesismentioning

confidence: 99%

“…Ophthalmoscopy of the optic nerve head shows a swollen optic nerve that bulges forward with edema present in the surrounding retinal nerve fiber layer. This disk swelling occurs when CSF pressure rises to between 17 and 45 mmHg [8,9] and is due to a loss of CSF outflow conductance. Fifty percent of patients will completely resolve within 3-6 months of CSF lowering treatment.…”

Section: Introductionmentioning

confidence: 99%

The translaminar pressure gradient in sustained zero gravity, idiopathic intracranial hypertension, and glaucoma

Berdahl

Morgan

2012

Medical Hypotheses

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“…[1][2][3][4][5][6][7] Prognosis is variable, with severe visual loss occurring in up to 10% of cases.8 Although few series have specifically evaluated racial differences in IIH, it has been suggested that black patients may have more severe outcomes from IIH.9 -11 The purpose of this study was to compare the characteristics of IIH in blacks and nonblacks.…”

Section: Introductionmentioning

confidence: 99%

Racial differences in idiopathic intracranial hypertension

Bruce

Preechawat²,

Newman³

et al. 2008

Neurology

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Objective-To evaluate racial differences in idiopathic intracranial hypertension (IIH).Methods-Medical records of all consecutive patients with definite IIH seen between 1989 and 2006 were reviewed. Demographics, associated factors, and visual function at presentation and follow-up were collected. Black patients were compared to non-black patients. (197 black, 253 non-black). Obesity, systemic hypertension, anemia, and sleep apnea were more common in blacks than in non-blacks (p≤0.01). Cerebrospinal fluid opening pressure was higher in blacks (40 vs. 34 cm CSF, p<0.001). Visual acuity, visual field loss, and degree of papilledema at presentation and follow-up were worse in blacks (p≤0.01). Diagnostic and therapeutic measures were similar between blacks and non-blacks, except for optic nerve sheath fenestration (p=0.01) and lumbar puncture (p=0.03), both more commonly performed on black patients. The relative risk of severe visual loss for blacks compared with non-blacks was 3.5 (95%CI 2.0-5.8, p<0.001) in at least one eye and 4.8 (95%CI 2.1-10.9, p<0.001) in both eyes. Logistic regression analysis supported race, anemia, body mass index, and male gender as independent risk factors for severe visual loss and suggested that racial differences may be partially accounted for by differences in CSF opening pressure, body mass index, and frequency of anemia. Results-We included 450 patientsConclusion-Black IIH patients were more likely than non-black IIH patients to have severe visual loss in at least one eye. This difference did not appear to result from diagnosis, treatment, or access to care, but may partially relate to differences in other risk factors. Black patients have a more aggressive disease and may need closer follow-up and lower thresholds for early intervention.

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Idiopathic intracranial hypertension in Dubai: nature and prognosis

Abstract: Idiopathic intracranial hypertension has relatively benign course in this part of the world and more aggressive treatment is not recommended.

Cited by 18 publications

References 23 publications

Idiopathic intracranial hypertension in the Middle East: A growing concern

Idiopathic intracranial hypertension in the Middle East: A growing concern

The translaminar pressure gradient in sustained zero gravity, idiopathic intracranial hypertension, and glaucoma

Racial differences in idiopathic intracranial hypertension

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