Idiopathic lipogranulomatosis of spleen and periaortic lymph nodes with noncaseating granulomas of liver

Rubinstein, Alan I.; Brenner, S

doi:10.1016/s0046-8177(82)80252-9

Cited by 16 publications

(3 citation statements)

References 14 publications

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“…This disease is relatively rare in the breast, most commonly occurring in the middle ear and mastoid process, and is also found in the parotid glands, [15] lymph nodes, [14] liver and spleen. [16] Surgical specimens are mostly yellowish-brown masses with soft [2] or solid texture. [1] The section surface has a sandy texture and is clearly demarcated from normal breast tissues.…”

Section: Histological Featuresmentioning

confidence: 99%

Multiple cholesterol granulomas of the breast: A case report and review of the literature

Jin

Miao

et al. 2023

Medicine

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Rationale: Cholesterol granuloma of the breast is a rare disease defined as chronic reactive inflammation of cholesterol crystals and foreign body giant cells. This disease can mimic breast cancer in the clinic as painless palpable hard nodules, and imaging shows irregular hypoechoic nodules with unclear boundaries. Therefore, the uncommon lesions can be easily misdiagnosed as breast cancer. Meanwhile, it can be easily neglected by clinicians because of poor understanding.Patient concerns: In this report, we present a rare case of multiple cholesterol granulomas of the breast, which was analyzed retrospectively and combined with all 11 relevant available studies in the last 50 years. Interventions:The patient had undergone multiple breast imaging inspections for breast nodules and had the local resection of nodules.Diagnoses: The patient was confirmed to have a final diagnosis of benign cholesterol granulomas but was initially considered as breast cancer.Outcomes: The patient did not complain of discomfort after surgery, and ultrasound reexamination 5 months after surgery showed no recurrence.Lessons: By retrospective analysis, dynamic contrast-enhanced magnetic resonance imaging and core needle biopsy can synergistically help clinicians distinguish it from other breast disease. To raise awareness of such a rare disease and reduce related misdiagnoses, we summarize the characteristics of cholesterol granulomas and recommend appropriate novel diagnosis and treatment regimens for patients with cholesterol granulomas.

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Section: Histological Featuresmentioning

confidence: 99%

Multiple cholesterol granulomas of the breast: A case report and review of the literature

Jin

Miao

et al. 2023

Medicine

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“…A cholesteroloma or cholesterol granuloma refers to a collection of cholesterol crystal clefts surrounded by foreign body giant cells and fibrous granulation tissue. Cholesterol granulomas commonly occur in the middle ear cavity or mastoid processes and are also reported in other organs such as the peritoneum, testis, parotid gland, thyroglossal duct, kidney, lymph node, and liver and spleen . A cholesteroloma of the breast is an uncommon lesion representing an inflammatory or reactive process, first described by Doring et al, Germany in 1974.…”

Section: Introductionmentioning

confidence: 99%

Cholesteroloma of the breast: A 10 year retrospective review of 79 cases with radiology correlation

et al. 2019

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A cholesteroloma or cholesterol granuloma of the breast is an uncommon lesion representing an inflammatory/reactive process with unclear etiology. In this study, we reviewed our 10‐year experience with cholesteroloma of the breast with clinical, radiologic, and histopathological correlation. Seventy‐nine cases were selected. The mean patient age was 57.7 (range 25‐90) years old. Patients had hypercholesterolemia with mean blood cholesterol level of 201 mg/dL (P < 0.001). The mean body mass index (BMI) was 26.7 kg/m2 (P = 0.1976). The indications for the breast biopsies were mass lesion on radiology (85.5%, n = 65) and microcalcifications (10.5%, n = 8). Of the 65 cases of the mass lesions, 52 presented as solid masses and 13 were cystic. On the diagnostic mammogram or ultrasound, 81.9% were BI‐RADS 4% and 6.9% were BI‐RADS 5. Macrocysts were the most common pathological finding associated with cholesteroloma suggesting the etiology of cholesteroloma may be the result of repair process from obstruction and rupture of the macrocysts. Six cases (9.2%) of cholesterolomas had persistent masses during follow‐up. The recognition of this lesion and radio‐pathological correlation can help us better understand this entity and distinguish it from its mimickers.

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“…Cholesterol granuloma (CG) is a histological term describing a granulomatous tissue reaction to cholesterol crystals precipitation. Although occasionally reported in different body sites such as the mandible, 1 orbital bones, 2 liver, 3 kidney, 4 brain, 5 breast, 6 testis, 7 and peritoneum, 8 CG develops most commonly in the temporal bone in association with chronic middle‐ear disease. It is extremely rare in the paranasal sinuses, and, when they are involved, the maxillary sinus tends to be the most commonly affected 9 .…”

Section: Introductionmentioning

confidence: 99%

Cholesterol Granuloma of the Maxillary Sinus Encountered during Floor Augmentation Procedure: A Case Report

Karaky

Baqain

Hassona

et al. 2010

Clin Implant Dent Rel Res

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Idiopathic lipogranulomatosis of spleen and periaortic lymph nodes with noncaseating granulomas of liver

Cited by 16 publications

References 14 publications

Multiple cholesterol granulomas of the breast: A case report and review of the literature

Multiple cholesterol granulomas of the breast: A case report and review of the literature

Cholesteroloma of the breast: A 10 year retrospective review of 79 cases with radiology correlation

Cholesterol Granuloma of the Maxillary Sinus Encountered during Floor Augmentation Procedure: A Case Report

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