Idiopathic maculopathy in eyes with regressed retinopathy of prematurity

Lee, Kyoung Min; Kim, Jeong Hun; Yu, Young Suk

doi:10.1007/s00417-010-1355-4

Cited by 8 publications

(1 citation statement)

References 22 publications

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“…42 Lately, dysfunctions of photoreceptors are detected in a significant number of older children formerly afflicted with ROP; these outer retinal dysfunctions are composed of defective dark adaptation because of rod dysfunction, 3 abnormal cone function, 43 and retinal depigmentation. 44 Moreover, the apparent progressive nature of these changes is suggested. 45 Hence, with increasing survival of extremely premature neonates (at higher risk of ROP), an insidious recognition of late-onset photoreceptor dysfunction is being observed.…”

Section: Discussionmentioning

confidence: 99%

Choroidal Involution Is Associated with a Progressive Degeneration of the Outer Retinal Function in a Model of Retinopathy of Prematurity

Zhou

Rivera

Bhosle

et al. 2016

The American Journal of Pathology

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Retinopathy of prematurity (ROP), the most common cause of blindness in premature infants, has long been associated with inner retinal alterations. However, recent studies reveal outer retinal dysfunctions in patients formerly afflicted with ROP. We have recently demonstrated that choroidal involution occurs early in retinopathy. Herein, we investigated the mechanisms underlying the choroidal involution and its long-term impact on retinal function. An oxygen-induced retinopathy (OIR) model was used. In vitro and ex vivo assays were applied to evaluate cytotoxic effects of IL-1β on choroidal endothelium. Electroretinogram was used to evaluate visual function. We found that proinflammatory IL-1β was markedly increased in retinal pigment epithelium (RPE)/choroid and positively correlated with choroidal degeneration in the early stages of retinopathy. IL-1β was found to be cytotoxic to choroid in vitro, ex vivo, and in vivo. Long-term effects on choroidal involution included a hypoxic outer neuroretina, associated with a progressive loss of RPE and photoreceptors, and visual deterioration. Early inhibition of IL-1β receptor preserved choroid, decreased subretinal hypoxia, and prevented RPE/photoreceptor death, resulting in life-long improved visual function in IL-1 receptor antagonist-treated OIR animals. Together, these findings suggest a critical role for IL-1β-induced choroidal degeneration in outer retinal dysfunction. Neonatal therapy using IL-1 receptor antagonist preserves choroid and prevents protracted outer neuroretinal anomalies in OIR, suggesting IL-1β as a potential therapeutic target in ROP.

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Section: Discussionmentioning

confidence: 99%

Choroidal Involution Is Associated with a Progressive Degeneration of the Outer Retinal Function in a Model of Retinopathy of Prematurity

Zhou

Rivera

Bhosle

et al. 2016

The American Journal of Pathology

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The macular findings on spectral-domain optical coherence tomography in premature infants with or without retinopathy of prematurity

et al. 2016

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The purpose of the study was to present spectral-domain optical coherence tomography (OCT) findings in premature infants with or without mild-to-severe retinopathy of prematurity (ROP). Seventy-two infants born <37 weeks of gestation were analyzed, prospectively. Group 1 (n = 18) included infants without ROP. Infants with stage 1, 2, or 3 ROP without indication for treatment formed the second group (n = 15). Group 3 (n = 21) included threshold cases, who would receive laser photocoagulation (LPC) after OCT examinations. Group 4 (n = 18) had already received LPC. The mean central foveal thickness (CFT) (μm) in right eyes was 194.27 ± 19.93, 207.67 ± 25.44, 224.29 ± 21.42, and 222.00 ± 37.80, for groups 1, 2, 3, and 4, respectively (p = 0.01). The presence of a well-formed foveal pit was documented in 60 % of right and 67 % of left eyes in group 1, while a well-formed foveal pit was observed in 14 % of right and 16 % of left eyes in group 3 (p < 0.05). Cystoid macular edema (CME) was shown in 29 % of right and 21 % of left eyes in group 3 (p < 0.05 for right eyes). CME was observed in two of right and left eyes in group 4. Epiretinal membrane (ERM) was shown in one right eye in group 3, two right and four left eyes in group 4 (p < 0.05 for left eyes). Thicker CFT, CME, and failure of a well-formed foveal pit could be related to the severity of ROP. The development of ERM could be the consequence of LPC.

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Ocular coherence tomography findings of an unusual maculopathy in retinopathy of prematurity after laser treatment

Lam

Shah

Lam

2020

Journal of American Association for Pediatric Ophthalmology and

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Idiopathic maculopathy in eyes with regressed retinopathy of prematurity

Abstract: Idiopathic maculopathy is a rare posterior polar change that differs from the cicatricial changes seen in retinopathy of prematurity, and is independent of prior laser photocoagulation. No progression was observed, and visual prognosis was fair.

Cited by 8 publications

References 22 publications

Choroidal Involution Is Associated with a Progressive Degeneration of the Outer Retinal Function in a Model of Retinopathy of Prematurity

Choroidal Involution Is Associated with a Progressive Degeneration of the Outer Retinal Function in a Model of Retinopathy of Prematurity

The macular findings on spectral-domain optical coherence tomography in premature infants with or without retinopathy of prematurity

Ocular coherence tomography findings of an unusual maculopathy in retinopathy of prematurity after laser treatment

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