Idiopathic Membranous Nephropathy: Outline and Rationale of a Treatment Strategy

Prognostic significance of glomerular and tubulointerstitial morphometry in idiopathic membranous nephropathy

“…Idiopathic membranous nephropathy (IMN) is one of the most common primary glomerulonephritides, accounting for 9.7% to 29.4% [3,9,17]. It is considered the most common cause of nephrotic syndrome in adults [22,25].…”

Balancing Cancer Risk and Efficacy of Using Cyclophosphamide to Treat Idiopathic Membranous Nephropathy

“…Two large controlled trials demonstrated improved renal survival with alkylating agents in combination with steroids (10,11). Additionally, cohort studies confirmed the benefits of cytotoxic therapies, with cyclophosphamide being the preferred agent (12)(13)(14). A recently published meta-analysis revealed significant reduction in ESRD in response to combined alkylating agent and corticosteroid therapy (15).…”

Minimal Change Nephrotic Syndrome Complicated with Malignant Ascites in a Patient with Type II Diabetes

“…Before arriving at the conclusion that nephrotic syndrome is etiologically linked to minimal change glomerular disease, the presence of alternative renal injuries, such as membranous nephropathy, which is one of the most common causes of nephrotic syndrome in adult patients (6), and nephrosclerosis due to a long history of hypertension, were suspected. Thus, there was a clinical benefit to performing a renal biopsy in the present patient, since it led us not only to diagnose her with minimal change nephrotic syndrome rather than of diabetic nephropathy, membranous nephropathy, or hypertensive nephrosclerosis, but also because initiating steroid treatment for nephrotic syndrome resulted in prompt remission.…”