Idiopathic muscular strictures of the sigmoid colon.

Cassano, Caesar; Torsoli, A

doi:10.1136/gut.9.3.325

Cited by 15 publications

(3 citation statements)

References 4 publications

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“…Morson (1963) has shown that the most consistent finding in 155 surgically resected specimens of 'diverticulitis' was the muscle abnormality, and his series included four specimens in which no diverticula could be demonstrated yet muscle thickening was present in every case. Four cases of idiopathic muscular strictures of the sigmoid resembling the muscular thickening of diverticular disease, have been reported recently by Cassano and Torsoli (1968). Painter and Truelove (1964) found that, in response to a therapeutic dose of morphine or an injection of prostigmine, the diverticula-bearing segments showed an excessive pressure activity while normal segments in the same patients gave a normal response.Thus, according to these workers, the area of the colon affected by diverticular disease acts differently from the rest of the colon.…”

Section: Discussionmentioning

confidence: 99%

Rectal and colonic studies after resection of the sigmoid for diverticular disease

Parks¹

1970

Gut

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Section: Discussionmentioning

confidence: 99%

Rectal and colonic studies after resection of the sigmoid for diverticular disease

Parks¹

1970

Gut

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“…Stricture formation secondary to a vascular accident or to a rare benign ulcer of the colon may be theoretically indistinguishable from an adhesion. An idiopathic muscular stricture of the colon, an entity described in the sigmoid and descending colon, manifests as a narrowing of the coJon with variation in caliber, smooth contours, and shelf-like margins (4,15). However, it is longer than the constriction produced by an adhesion.…”

Section: Discussionmentioning

confidence: 99%

Right Colonic Adhesions

Twersky¹,

Himmelfarb²

1976

Radiology

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Adhesive bands may cause narrowing of the colon. The radiographic appearance may show evidence of a sharp, localized narrowing and smooth mucosal contour. Adhesions involving the ascending colon may also precipitate acute colonic obstruction due to formation of a cecal bascule. The nature of the adhesive bands and their relationship to prior surgery, to anomalies of mesenteric fixation, and to appendices epiploicae are discussed.

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“…Pineal extracts have also been reported to inhibit adrenocortical function in rats (39) and electric-shock-induced seizures in cats (40 presses compensatory adrenal hypertrophy following unilateral adrenalectomy and decreases the thickness of the zona fasciculata and the plasma corticosterone con centration in intact animals (39,41).…”

Section: Effects Of Mammalian Pineal Extracts On Gonadal Functionmentioning

confidence: 97%

The Pharmacology of the Pineal Gland

Minneman¹,

Wurtman²

1976

Annu. Rev. Pharmacol. Toxicol.

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Only recently have a sufficient number of publications been available to legitimize a review of the pharmacology of the mammalian pineal organ. Two decades ago Kitay & Altschule reviewed the world literature on pineal physiology, which comprises several thousand papers, and concluded only that removal of the pineal, or administration of pineal extracts, somehow affected pigmentation in lower vertebrates and gonadal function in mammals (1). As the studies described below demonstrate, much more information is now available concerning the pharmacology of the pineal. This review subdivides present knowledge into two areas: (a) the effects on mammals of administering pineal extracts or pure synthetic or natural pineal constituents and (b) the effects of drugs and hormones on the pineal itself. As might be anticipated, the bulk of studies cited in both categories deals with the pineal hormone, melatonin. Melatonin was first isolated from bovine pineal extracts in 1958 by Lerner and his colleagues (2), who used as a marker the capacity of the hormone to aggregate the pigment granules in amphibian melanophores around the cell nucleus. Five years later, Wurtman et al (3) showed that melatonin affected a physiological function in mammals, that is, the size and secretion of the ovary, and subsequent studies have demonstrated that melatonin administration also modifies the growth, composition, and functional activities of numerous other organs. Only recently an assay was developed that allows quantification of the melatonin in human urine (4). The concentrations of the compound vary with a characteristic daily rhythm, peaking at night. The pineal's apparent role as the sole or major source of melatonin, the presence of melatonin in urine, and the demonstration that physiologic effects follow a pinealectomy or the administration of melatomin seem to justify labeling it a pineal hormone. Melatonin synthesis and pineal biosynthetic activity are generally controlled by the sympathetic nerves of this organ (5,6). Therefore, it should not be surprising that drugs known to modify the synthesis, release, or metabolism of norepinephrine in peripheral organs also affect pineal function. Melatonin is itself a derivative of another biogenic amine, serotonin, whose metabolism and actions are also affected by numerous drugs. Indeed, the pineal has often provided an apt tool for examining monoaminergic mechanisms for pharmacologists not specifically concerned with its particular functional properties.

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Idiopathic muscular strictures of the sigmoid colon.

Cited by 15 publications

References 4 publications

Rectal and colonic studies after resection of the sigmoid for diverticular disease

Rectal and colonic studies after resection of the sigmoid for diverticular disease

Right Colonic Adhesions

The Pharmacology of the Pineal Gland

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