Idiopathic myelofibrosis in pregnancy: A case report and review of the literature

Pregnancy and its management in the Philadelphia negative myeloproliferative diseases

“…Myelofibrosis is the MPD that is least common in patients of child bearing age (McNally et al , 1999) and, combined with its worse prognosis, probably explains the paucity of published information for pregnancy in this condition. Indeed the literature comprises only four pregnancies in two patients (Taylor et al , 1992; Gotic et al , 2001) and is summarized in Table II. It is difficult to interpret such limited data but the parallels with pregnancy outcome in ET and PV are apparent and the pathophysiology is likely to be similar.…”

Splenomegaly, pancytopenia and pregnancy: a case report and review of the literature

“…Idiopathic myelofibrosis is a rare myeloproliferative disorder of unknown aetiology characterized by excessive accumulation of connective tissues in the bone marrow in association with anemia, splenomegaly and extra-medullary hematopoeisis. 3 In our case, the patient was investigated for possible malignancy, but the blood tests were not suspicious and the bone marrow biopsy, done twice, was negative for malignancy. In addition, the splenectomy specimen failed to identify any malignant cells.…”

“…In these cases, the workup should include a bone marrow biopsy to rule out a malignancy, the most common in the reproductive age group being leukaemia or lymphoma and rarely a myeloproliferative disorder. [1][2][3] Leukaemias, the hairy cell type, are rare during pregnancy and those patients generally show marked improvement after splenectomy. 1 Coincident lymphoma and pregnancy is also rare occurring in 1/1000-1/6000 deliveries.…”

The management and outcome of four pregnancies in women with idiopathic myelofibrosis

“…This pregnancy was successful whilst two previous pregnancies had resulted in still‐births (see Table I). Asprin +/− low molecular weight heparin was not used in the management of any of these previously reported patients (Taylor et al , 1992; Gotic et al , 2001). Overall, 2/4 previously described pregnancies resulted in a live birth, one of which was managed with interferon α, and the other with supportive treatment only.…”

“…Only four pregnancies in two patients with PMF have previously been described. Taylor et al (1992) described a single pregnancy in one patient without previous thrombosis which was managed conservatively with a live birth following elective induction of labour at 36 weeks. No specific treatment for PMF was given.…”