Idiopathic Parkinson’s Disease, Osteoporosis, and Hip Fractures: A Case Report

Rison, Richard A.; Richardson, Kelsey

doi:10.1159/000323665

Cited by 6 publications

(4 citation statements)

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“…Significant Spearman’s correlations were observed between BMD and the severity of PD, strongly indicating that the grade of osteoporosis may reflect the progression of PD. We therefore propose the following reasons for osteoporosis: (1) tremor, bradykinesia, and rigidity obviously decrease outdoor activities, including weight-bearing exercise, which may increase bone deposition and decrease bone re-absorption (Rison and Richardson, 2011 ); and (2) some NMS, such as depression and dementia, cause patients to be unwilling to participate in daily outdoor activities and to get less sunlight exposure (Rison and Richardson, 2011 ). This hypothesis is indirectly reflected in our results (Table 5 ).…”

Section: Discussionmentioning

confidence: 99%

Lower Bone Mineral Density in Patients with Parkinson’s Disease: A Cross-Sectional Study from Chinese Mainland

Gao

Wei

Liao

et al. 2015

Front. Aging Neurosci.

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Key pointsSignificantly lower BMD in PD compared to healthy subjects in both genders.Less than 35 mg2/dl2 of Ca–P product in >80% of PD patients.Significant correlations between BMD and severity of PD.Lower BMD at H&Y stage III/IV than that at H&Y stage I/II.ObjectivesAlthough several lines of evidence have suggested that patients with Parkinson’s disease (PD) have a higher risk of osteoporosis and fracture, the association between bone mineral density (BMD) and severity of PD patients is unknown.MethodsWe performed a cross-sectional study of 54 patients with PD and 59 healthy age-matched controls. Multiple clinical scales were used to evaluate the severity of PD, and serum levels of calcium, phosphorus, and homocysteine were measured to determine BMD’s association with PD severity.ResultsBMD in PD patients was significantly lower than that in healthy controls. The BMD scores of the spine, femoral neck (FN), and hip were lower in females than in males in the healthy group. In the PD group, BMD in the hip was significantly lower in females compared to males. There was a negative correlation between daily l-DOPA dosage and BMD in the spine and hip in the PD group, while BMD in the spine, neck, and hip was significantly correlated with severity of PD. Besides, we found that among the lumbar spine (LS), FN, and hip, bone loss in the LS was the most severe in PD patients based on the T-scores.ConclusionOur findings support the hypothesis that patients with PD have a higher risk of osteoporosis, and that low BMD in the spine, FN, and hip may indirectly reflect the severity of PD. Our findings have prompted us to pay more attention to osteoporosis in the LS in Chinese PD patients.

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Section: Discussionmentioning

confidence: 99%

Lower Bone Mineral Density in Patients with Parkinson’s Disease: A Cross-Sectional Study from Chinese Mainland

Gao

Wei

Liao

et al. 2015

Front. Aging Neurosci.

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“…Community‐dwelling older adults with PD are twice as likely as those without PD to fall and nine times as likely to have recurrent falls . PD is also associated with greater risk of fall‐related injuries, including hip fractures, although there is a smaller disparity in the rates of upper limb fractures …”

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confidence: 99%

Falls and Parkinson's Disease: Evidence from Video Recordings of Actual Fall Events

Weaver

Robinovitch

Laing

et al. 2016

J American Geriatrics Society

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“…Níveis elevados de homocisteína são considerados um fator independente para o risco de fraturas. 46 Além disso, a hipovitaminose D enquanto fator possivelmente relacionado a HO na DP, também poderia elevar os riscos de queda. Um estudo evidenciou menores níveis de vitamina D em pacientes com DP associado a HO quando comparados a pacientes com DP sem HO.…”

Section: Hipotensão Ortostática E Risco De Quedasunclassified

Hipotensão Ortostática na Doença de Parkinson: Revisão

Vilaça¹,

Leite²,

Filho³

et al. 2019

REVA

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Objetivo: Revisão da literatura abordando o diagnóstico, fisiopatologia, complicações e tratamento da hipotensão ortostática em paciente com Doença de Parkinson. Método: Revisão não sistemática utilizando a plataforma Google Acadêmico de artigos abordando a hipotensão postural na Doença de Parkinson. Resultados e Discussão: Foram utilizados 65 artigos em inglês para confecção desta revisão. Conclusão: A hipotensão ortostática é um sintoma não motor frequentemente subdiagnosticado em pacientes com Doença de Parkinson. Pode estar associada a riscos de quedas com fraturas, déficit cognitivo e eventos vasculares, apresentando difícil tratamento. Recomenda-se rastreio da presença de hipotensão ortostática em todos os pacientes com Doença de Parkinson.Palavras-Chave: hipotensão ortostática, Doença de Parkinson, acidentes por quedas

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Idiopathic Parkinson’s Disease, Osteoporosis, and Hip Fractures: A Case Report

Cited by 6 publications

References 6 publications

Lower Bone Mineral Density in Patients with Parkinson’s Disease: A Cross-Sectional Study from Chinese Mainland

Lower Bone Mineral Density in Patients with Parkinson’s Disease: A Cross-Sectional Study from Chinese Mainland

Falls and Parkinson's Disease: Evidence from Video Recordings of Actual Fall Events

Hipotensão Ortostática na Doença de Parkinson: Revisão

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