Idiopathic Perforated Appendicitis in Neonates and Infants

Alhindi, Saeed; Ayoub, Barrak

doi:10.12816/0047505

Cited by 1 publication

(4 citation statements)

References 18 publications

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“…With cross‐referencing, eight additional eligible articles were identified. In total, 131 articles were included in this systematic review 3,6,12–140 . Figure 1 provides the PRISMA flowchart.…”

Section: Resultsmentioning

confidence: 99%

“…In 36 (20%) of the 178 surgically treated patients with abdominal appendicitis an ileostomy or colostomy was placed. Reported indications were: N = 5 suspicion or confirmation of Hirschsprung disease, N = 2 ischemic distal ileum or necrotic patches, N = 1 segmental ileal loop volvulus with perforated appendicitis, N = 1 no specific reason mentioned, but preoperative treatment for NEC, N = 26 patients with presumed concurring NEC, and N = 1 unclear 13,45,53,59,80,115,129 . A bowel resection with primary anastomosis was performed in an additional seven (4%) of the 178 surgically treated patients with abdominal appendicitis (postoperative complications not included).…”

Section: Resultsmentioning

confidence: 99%

“…In total, 131 articles were included in this systematic review. 3 , 6 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ...…”

Section: Resultsmentioning

confidence: 99%

“…Reported indications were: N = 5 suspicion or confirmation of Hirschsprung disease, N = 2 ischemic distal ileum or necrotic patches, N = 1 segmental ileal loop volvulus with perforated appendicitis, N = 1 no specific reason mentioned, but preoperative treatment for NEC, N = 26 patients with presumed concurring NEC, and N = 1 unclear. 13 , 45 , 53 , 59 , 80 , 115 , 129 A bowel resection with primary anastomosis was performed in an additional seven (4%) of the 178 surgically treated patients with abdominal appendicitis (postoperative complications not included). Reported indications were: N = 2 ileocaecal resection due to perforation of the caecum or fistula of the appendix into caecum, N = 1 resection of a part of ascending colon due to local lesion caused by adherent appendix, N = 1 resection terminal ileum due to adherent appendix and cystic lesion, N = 1 Meckel's diverticulum, N = 1 adherent ileal loop, N = 1 old perforation terminal ileum.…”

Section: Resultsmentioning

confidence: 99%

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Appendicitis and its associated mortality and morbidity in infants up to 3 months of age: A systematic review

The,

Derikx

et al. 2023

Health Science Reports

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Background and AimsAlthough appendicitis is rare in young infants, the reported mortality is high. Primary aim of this systematic review was to provide updated insights in the mortality and morbidity (postoperative complications, Clavien‐Dindo grades I–IV) of appendicitis in infants ≤3 months of age. Secondary aims comprised the evaluation of patient characteristics, diagnostic work‐up, treatment strategies, comorbidity, and factors associated with poor outcome.MethodsThis systematic review was reported according to the PRISMA statement with a search performed in Pubmed, Embase and Web of Science (up to September 5th 2022). Original articles (published in English ≥1980) reporting on infants ≤3 months of age with appendicitis were included. Both patients with abdominal appendicitis and herniated appendicitis (such as Amyand's hernia) were considered. Data were provided descriptively.ResultsIn total, 131 articles were included encompassing 242 cases after identification of 4294 records. Overall, 184 (76%) of the 242 patients had abdominal and 58 (24%) had herniated appendicitis. Two‐hundred (83%) of the patients were newborns (≤28 days) and 42 (17%) were infants between 29 days and ≤3 months of age. Either immediate, or after initial conservative treatment, 236 (98%) patients underwent surgical treatment. Some 168 (69%) patients had perforated appendicitis. Mortality was reported in 20 (8%) patients and morbidity in an additional 18 (8%). All fatal cases had abdominal appendicitis and fatal outcome was relatively more often reported in newborns, term patients, patients with relevant comorbidity, nonperforated appendicitis and those presented from home.ConclusionMortality was reported in 20 (8%) infants ≤3 months of age and additional morbidity in 18 (8%). All patients with fatal outcome had abdominal appendicitis. Several patient characteristics were relatively more often reported in infants with poor outcome and adequate monitoring, early recognition and prompt treatment may favour the outcome.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%