Idiopathic polypoidal choroidal vasculopathy: a review of literature with clinical update on current management practices

Sahu, Yamini; Chaudhary, Niharika; Joshi, Mukesh C.; Gandhi, Ashok

doi:10.1007/s10792-020-01620-0

Cited by 8 publications

(23 citation statements)

References 82 publications

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“…Increased inflammation seems to be one of the etiologic key factors in AMD, PCV, and CVD, and different inflammation markers have been shown to be strongly associated with both late AMD and CVD 5,7,22,86 . Moreover, many of the aforementioned risk factors are associated with inflammation and vascular alterations.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies reported an estimated prevalence of over 25% in subjects above the age of 60 years and a 15% increase in AMD incidence in individuals aged 75 years and older 1–3 . Polypoidal choroidal vasculopathy (PCV), a disease highly prevalent in Asian populations, has been considered a variant of neovascular AMD and reported to share similar risk factors 4,5 . AMD is a complex multifactorial disease with genetic and environmental risk factors 2,4–7 .…”

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confidence: 99%

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Age-Related Macular Degeneration and Cardiovascular Diseases: Revisiting the Common Soil Theory

Mauschitz

Finger

2022

Asia-Pacific Journal of Ophthalmology

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Age-related macular degeneration (AMD), a complex disease associated with aging, remains one of the leading causes of visual loss in high-income countries and its prevalence is expected to increase over the next decades. Polypoidal choroidal vasculopathy has been considered a variant of neovascular AMD and is highly prevalent in Asian populations. Similarly, cardiovascular disease (CVD)—another complex disease associated with aging—is a leading cause of morbidity and mortality in high-income countries and its prevalence is also expected to increase due to population aging. Previous studies reported an increased risk for CVD in AMD patients, indicating an underlying “common soil.” Reviewing the current literature, consistent evidence for common risk factors and mutual comorbidity was identified for both diseases. Cardiovascular risk factors include smoking, diet, and low levels of physical activity, which also play a role in AMD pathogenesis. Several studies demonstrated AMD patients to be at higher risk for CVD compared to the general older population. The complexity of both diseases, however, complicates research on their relation, and thus studies ought to be interpreted with caution. Herein we present an overview of selected studies and their main “take-home messages” on this topic, and hypothesize on the patho-etiologic “common ground” of these 2 diseases.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Age-Related Macular Degeneration and Cardiovascular Diseases: Revisiting the Common Soil Theory

Mauschitz

Finger

2022

Asia-Pacific Journal of Ophthalmology

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“…The genetics of PCV are not as well investigated as those of AMD. PCV and AMD share some single nucleotide polymorphisms in complement and inflammatory genes, but other genetic markers unique to PCV could not consistently be identified [1,2] More recently, PCV was classified as part of the pachychoroid disease spectrum, which includes pachychoroid pigment epitheliopathy and central serous chorioretinopathy [3]. This classification is, however, not consistent with PCV being a subtype of AMD.…”

Section: Introductionmentioning

confidence: 99%

“…They may present as singular nodules or multiple grape-like clusters of hyperfluorescence together with atypical choroidal vessels forming branched vascular networks. The EVEREST study and the Japanese Study Group have defined diagnostic criteria based on ICG angiography and funduscopic appearance [1,2]. In contrast to ICG imaging, spectral domain optical coherence tomography (SD-OCT) is noninvasive and more readily available.…”

Section: Introductionmentioning

confidence: 99%

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Thermal Laser Monotherapy for Extrafoveal Polypoidal Choroidal Vasculopathy

Radeck

Helbig

Valmaggia

et al. 2021

Klin Monbl Augenheilkd

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Introduction Polypoidal choroidal vasculopathy (PCV) is a vascular disease of the choroid. Diagnosis is mainly based on polypoidal aneurysm-like lesions seen in indocyanine green (ICG) angiography. Various therapeutic options have been proposed. Methods Outcomes of 10 cases with extrafoveal PCV and consecutive macular edema treated with thermal laser are reported. Diagnosis of PCV was confirmed by ICG angiography. Results Upon successful occlusion of the polyps in 10 eyes after thermal laser treatment demonstrated in ICG angiography, a regression of central foveal edema was seen in optical coherence tomography and color fundus photography. Visual acuity improved from logMAR 0.8 to logMAR 0.3. Follow-up ranged from 4 months to 15 years, with a median of 1 year. Two eyes had a recurrence of exudative maculopathy 5 and 7 years after laser treatment, respectively. Conclusion A careful differentiation between various subforms of exudative maculopathy using fluorescein and ICG angiography can identify certain selected patients with extrafoveal PCV, for whom thermal laser monotherapy can be a therapeutic option.

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Association of HERPUD1 genetic variant rs2217332 with age-related macular degeneration and polypoidal choroidal vasculopathy in an Indian cohort

Alagappan

Ramaswamy

Sundaramoorthy

et al. 2022

Graefes Arch Clin Exp Ophthalmol

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Idiopathic polypoidal choroidal vasculopathy: a review of literature with clinical update on current management practices

Cited by 8 publications

References 82 publications

Age-Related Macular Degeneration and Cardiovascular Diseases: Revisiting the Common Soil Theory

Age-Related Macular Degeneration and Cardiovascular Diseases: Revisiting the Common Soil Theory

Thermal Laser Monotherapy for Extrafoveal Polypoidal Choroidal Vasculopathy

Association of HERPUD1 genetic variant rs2217332 with age-related macular degeneration and polypoidal choroidal vasculopathy in an Indian cohort

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