Idiopathic Rapidly Progressive Glomerulonephritis

Couser, William G.

doi:10.1159/000166586

Cited by 72 publications

(29 citation statements)

References 72 publications

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“…Several authors have pointed out that DPH can be a more frequent finding in non-anti-GBM Ab mediated Goodpasture's syndrome than has been reported so far [2][3][4], Our experience agrees with these observations and with the comments of Boyce and Holdsworth [1], The pathogenesis of DPH in the cases not mediated by anti-GBM Ab or not associated with vasculitis, remains com pletely unknown. Furthermore, in some cases of anti-GBM Ab Goodpasture's syndrome with DPH, the IF studies have not showed deposition of immunoglobulins in lung tissue [5], the same as our patient 1 (table I).…”

supporting

confidence: 88%

Diffuse Pulmonary Haemorrhage and Crescentic Glomerulonephritis

Gutierrez-Rodero¹,

Andrés²,

Praga³

1987

Nephron

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supporting

confidence: 88%

Diffuse Pulmonary Haemorrhage and Crescentic Glomerulonephritis

Gutierrez-Rodero¹,

Andrés²,

Praga³

1987

Nephron

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“…RPGN is a usually fatal disease, the prompt and correct diagnosis of which is predicated upon a renal biopsy [28], Its management by hemodialysis, pulse methylprednisolone therapy, and plasmapheresis is essential if the patient is to have a chance of survival [29][30][31][32], If the disease develops in a patient receiving penicillamine, the drug should be with drawn promptly.…”

Section: Discussionmentioning

confidence: 99%

Rapidly Progressive Glomerulonephritis in a Patient with Rheumatoid Arthritis during Treatment with High-Dosage <i>D</i>-Penicillamine

et al. 1985

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A patient with advanced rheumatoid arthritis and severe clinical manifestations of rheumatoid vasculitis died of acute renal failure after 30 months of treatment with high-dosage D-penicillamine. She had had no signs of adverse drug reactions until the terminal illness. Although streptococcal pharyngitis was diagnosed late in her disease, penicillamine-induced immune complex glomerular damage is considered more likely than poststreptococcal glomerulonephritis, because her microscopic hematuria preceded diagnosis of pharyngitis. Postmortem examination disclosed findings suggestive of rapidly progressive glomerulonephritis of immune complex pathogenesis. The short period of microscopic hematuria and the rapidity of development of renal failure before death emphasize the need for frequent monitoring of renal function and prompt discontinuation of D-penicillamine treatment upon detection of otherwise unexplained hematuria. There is urgent need for early immunological evaluation, renal biopsy, and vigorous therapeutic measures.

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“…Renal function improved in 5 cases (No. [1][2][3][4][5], and the percentage of restoration was comparable to that observed at the first attack. Deaths occurred in 2 of the 6 patients; patient No.…”

Section: Resultsmentioning

confidence: 59%

“…Etiologically, the nephritis may be due to antiglomerular basement membrane anti bodies, to deposited immune complexes or be termed idiopathic when immune deposits are not detected by 1 Paris of this work were presented at the 9th International Con gress of Nephrology. Abstracts 122A, Los Angeles 1984. immunofluorescence techniques [1,2], Recently devel oped therapeutic approaches combining oral corticoste roids, immunosuppressive agents (cyclophosphamide) or pulse méthylprednisolone in open studies [3][4][5][6][7][8] and/or plasma exchange in prospective studies [9,10] appear to alter positively the natural history of idio pathic RPGN. allowing prolonged kidney survival.…”

Section: Introductionmentioning

confidence: 99%

Relapses of Idiopathic Diffuse Crescentic Glomerulonephritis without Immune Deposits: Report of 6 Cases

Belghiti¹,

Lévy²,

Rifle³

et al. 1987

Am J Nephrol

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Idiopathic diffuse crescentic glomerulonephritis without immune deposits is a variant of rapidly progressive glomerulonephritis which can account for up to 40% of crescentic nephritis. The prognosis may depend on both the severity of histological injury at presentation and the efficacy of treatment. Recent advances in therapy have improved the outlook further, and prolonged stable remissions with mild renal failure can occur which contrast with the previously common evolution towards end-stage renal failure within a few weeks. However, relapses in otherwise stable remission may be seen, and we describe a series of 6 acute relapses interrupting such prolonged remissions. The relapses were defined by clinical and histological means. This modification of the natural history of some crescentic glomerulonephritis may reflect new therapeutic strategies, and the relapses may reflect a cyclical nature to the disease evolution which was previously hidden by hemodialysis. The possibility of successive flares suggests that kidney biopsies should be repeated when a rapid deterioration of renal function occurs, since treatment such as high-dose steroids and/or plasma exchange can be again effective if started early.

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Idiopathic Rapidly Progressive Glomerulonephritis

Cited by 72 publications

References 72 publications

Diffuse Pulmonary Haemorrhage and Crescentic Glomerulonephritis

Diffuse Pulmonary Haemorrhage and Crescentic Glomerulonephritis

Rapidly Progressive Glomerulonephritis in a Patient with Rheumatoid Arthritis during Treatment with High-Dosage <i>D</i>-Penicillamine

Relapses of Idiopathic Diffuse Crescentic Glomerulonephritis without Immune Deposits: Report of 6 Cases

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