Idiopathic retroperitoneal fibrosis: idiopathic or secondary to atherosclerosis?

Maaten, J ter

doi:10.1016/s0300-2977(99)00120-5

Cited by 2 publications

(2 citation statements)

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“…Retroperitoneal fibrosis is an inflammatory disease characterized by a periaortic fibrous mass extending throughout the retroperitoneum with consequent obstruction of adjacent organs, particularly the ureters 57–66 . The majority of cases are idiopathic, but some may be related to aortofemoral graft surgery, radiation, prior retroperitoneal surgery, or pergolide therapy for Parkinson’s disease.…”

Section: Review Of Intra‐abdominal Spindle Cell Lesionsmentioning

confidence: 99%

Intra‐abdominal spindle cell lesions: a review and practical aids to diagnosis

Al‐Nafussi

Wong

2001

Histopathology

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Intra-abdominal spindle cell lesions are uncommon and often present a diagnostic challenge. An important group of such lesions are the gastrointestinal stromal tumours. Other intra-abdominal spindle cell lesions include fibromatosis, various sarcomas-in particular, leiomyosarcoma, liposarcoma, and malignant peripheral nerve sheath tumour-and, in women, endometrial stromal sarcoma. Less common lesions are inflammatory myofibroblastic tumours, the mesenteric spindle cell reactive lesions, retroperitoneal fibrosis, and solitary fibrous tumour. A variety of intra-abdominal tumours of nonmesenchymal origin may have a spindle cell/sarcomatoid morphology; these include sarcomatoid carcinoma, malignant melanoma and, in women, sarcomatoid granulosa cell tumour. Finally, metastatic sarcomas from pelvic or extra-abdominal organs need also be considered. A set of practical aids to the diagnosis of intra-abdominal spindle cell lesions is presented to assist pathologists dealing with such lesions, particularly with regards to the consideration of differential diagnoses.

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Section: Review Of Intra‐abdominal Spindle Cell Lesionsmentioning

confidence: 99%

Intra‐abdominal spindle cell lesions: a review and practical aids to diagnosis

Al‐Nafussi

Wong

2001

Histopathology

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“…A pathogenetic role of atherosclerosis (ATS) in the development of CP has been suggested and supported by several previous observations [3, 4]. In the entities included in CP, except for the degree of aortic dilatation, the histopathological findings appear similar between idiopathic RPF and IAAA [5]. In idiopathic RPF, the aorta is not dilated and the surrounding fibroinflammatory tissue might or might not encase adjacent structures; in IAAA, the tissue develops around a dilated aorta, but does not cause obstructions, and perianeurysmal RPF involves an inflammatory aneurysm, the surrounding tissue of which entraps the adjacent organs (fig.…”

Section: Introductionmentioning

confidence: 55%

Rethinking the Triggering Inflammatory Processes of Chronic Periaortitis

Meier

Vogt²,

Blanc³

2006

Nephron Exp Nephrol

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Chronic periaortitis (CP) is an uncommon inflammatory disease which primarily involves the infrarenal portion of the abdominal aorta. However, CP should be regarded as a generalized disease with three different pathophysiological entities, namely idiopathic retroperitoneal fibrosis (RPF), inflammatory abdominal aortic aneurysm and perianeurysmal RPF. These entities share similar histopathological characteristics and finally will lead to fibrosis of the retroperitoneal space. Beside fibrosis, an infiltrate with variable chronic inflammatory cell is present. The majority of these cells are lymphocytes and macrophages as well as vascular endothelial cells, most of which are HLA-DR-positive. B and T cells are present with a majority of T cells of the T-helper phenotype. Cytokine gene expression analysis shows the presence of interleukin (IL)-1α, IL-2, IL-4, interferon-γ and IL-2 receptors. Adhesion molecules such as E-selectin, intercellular adhesion molecule-1 and the vascular cell adhesion molecule-1 were also found in aortic tissue, and may play a significant role in CP pathophysiology. Although CP pathogenesis remains unknown, an exaggeratedinflammatory response to advanced atherosclerosis (ATS) has been postulatedto be the main process. Autoimmunity has also beenproposed as a contributing factor based on immunohistochemical studies. The suspected allergen may be a component of ceroid, which is elaborated within the atheroma. We review the pathogenesis and the pathophysiology of CP, and its potential links with ATS. Clinically relevant issues are summarized in each section with regard to the current working hypothesis of this complex inflammatory disease.

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Idiopathic retroperitoneal fibrosis: idiopathic or secondary to atherosclerosis?

Cited by 2 publications

References 0 publications

Intra‐abdominal spindle cell lesions: a review and practical aids to diagnosis

Intra‐abdominal spindle cell lesions: a review and practical aids to diagnosis

Rethinking the Triggering Inflammatory Processes of Chronic Periaortitis

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