Idiopathic steatorrhoea and idiopathic pulmonary haemosiderosis.

Lane, Devin; Hamilton, W.S.

doi:10.1136/bmj.2.5753.89

Cited by 62 publications

(53 citation statements)

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“…In the cases reviewed, different clinical situations explained the development of hemorrhagic events, such as coagulopathy due to vitamin K malabsorption [4,15,20,23,32,44,45,47], celiac crisis [8,13], LHS [14,15,17,18,[33][34][35][36][37][38][39][40], portal hypertension [23], or digestive tumors [19,21,25,41].…”

Section: Discussionmentioning

confidence: 99%

“…Idiopathic pulmonary hemosiderosis was described initially by Virchow in 1864 and characterized by the triad hemoptysis, iron deficiency anemia, and pulmonary infiltrates [35]. In 1971, the IPH presence was described in a 23-year-old man with idiopathic steatorrhea (LHS) [63]. The pulmonary symptomatology in LHS starts usually in childhood, and only 25% of all patients have an adult onset [14,35].…”

Section: Discussionmentioning

confidence: 99%

“…Besides coagulopathy, diffuse alveolar hemorrhage with idiopathic pulmonary hemosiderosis (IPH) has been described in CD, an association also known as the Lane Hamilton syndrome (LHS) [14,15,17,18,[33][34][35][36][37][38][39][40] and presenting with hemoptysis. Moreover, intestinal tumors [19,21,25,41] or variceal bleeding [23] can determine digestive hemorrhage.…”

Section: Introductionmentioning

confidence: 99%

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Hemorrhagic Events in Adult Celiac Disease Patients. Case Report and Review of the Literature

Dima

Jurcuţ²,

Manolache³

et al. 2018

JGLD

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Background & Aims: Celiac disease (CD) presents with a wide spectrum of extra-digestive symptoms, including hemorrhagic manifestations. The aim of this review was to conduct an extensive analysis of the hemorrhagic events reported in adult CD patients.Methods: Case report and review of the literature. Pubmed (MEDLINE) database search from January 1970 onwards was performed using the medical subject headings [MeSH] terms “celiac disease” AND “blood coagulation disorders”, “hemorrhage”, “hematoma”, “hematuria”, “hemoptysis”, “epistaxis”, “hemosiderosis”.Only case reports were identified on the search theme. Information on patients’ characteristics, diagnostic features, coagulation parameters, symptomatology duration, and evolution under treatment were systematically collected and summarized.Results: We present the case of a 40-year-old man hospitalized for spontaneous muscular hematomas, in whom CD was diagnosed. We performed a review of the literature and summarized the published case reports of 46 CD patients, aged between 19 and 74 years, 64% of male gender. In 25% of cases, the symptomatology was present for more than 5 years prior to CD diagnosis. The clinical hemorrhagic events were as follows: 15 patients had gastrointestinal bleeding, 9 hemoptysis, 4 epistaxis, 6 hematuria, 8 cutaneous hematoma, petechia or ecchymoses, and only in 1 case hemarthrosis, hemorrhagic vesicular dermatitis, subcortical hemorrhage, or adrenal hemorrhage. Sixty percent of the patients had digestive symptoms, while the rest had only extradigestive CD involvement. The Lane Hamilton syndrome was defined in 15 patients. The evolution under a gluten-free diet was favorable in most cases.Conclusion: This review of case reports aims to increase awareness to hemorrhagic events, rare but possible life-threatening conditions, as part of the CD clinical spectrum. To the best of our knowledge, this is the first review of all types of hemorrhagic events in adult CD patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hemorrhagic Events in Adult Celiac Disease Patients. Case Report and Review of the Literature

Dima

Jurcuţ²,

Manolache³

et al. 2018

JGLD

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“…3 La hemosiderosis pulmonar idiopática suele manifestarse en forma aislada, pero en ocasiones se presenta en forma conjunta con la enfermedad celíaca. Dicha asociación, conocida como síndrome de Lane-Hamilton, 4 podría deberse a que ambas entidades comparten una vía patogénica común.…”

Section: Introductionunclassified

Hemorragia pulmonar asociada a enfermedad celíaca

et al. 2012

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“…Persistent bleeding can cause iron deposition in the lung parenchyma, as well as iron-deficiency anemia and pulmonary fibrosis. (1) The association between pulmonary hemosiderosis and celiac disease was first reported by Lane & Hamilton in 1971, (2) and related pathophysiological phenomena have yet to be fully elucidated. In most cases, pulmonary hemosiderosis presents with fever and anemia, which are accompanied by respiratory symptoms, such as cough, hemoptysis, and dyspnea.…”

Section: To the Editormentioning

confidence: 99%