Idiopathic sterile pyogranulomatous lymphadenitis in a nine‐month‐old springer spaniel

Abstract

A nine-month-old, intact male springer spaniel was presented with acute mandibular lymphadenopathy seven days following exploratory coeliotomy and biopsy of an enlarged mesenteric lymph node. Histology was consistent with sterile severe necrotising pyogranulomatous inflammation. An underlying cause of the granulomatous lymphadenitis could not be identified. The dog responded to prednisolone, showing complete resolution of the clinical signs. This could be an unusual presentation of canine juvenile cellulitis, without a cutaneous component and without initial submandibular or prescapular lymphadenopathy.

Characterisation and outcome of idiopathic pyogranulomatous lymphadenitis in 64 English springer spaniel dogs

“…A similar clinical presentation was reported in a 9‐month ESS with idiopathic PGL (Fraga‐Manteiga et al . ), but in that case, thoracic radiographs were unremarkable. Similarly, while vomiting and diarrhoea were reported in a quarter of cases, abdominal imaging was frequently unremarkable.…”

“…, Fraga‐Manteiga et al . ), and most appear to show signs of a systemic or multi‐organ inflammatory process. Major signs including skin lesions, lethargy and decreased appetite were reported in more than half of the dogs.…”

“…, Fraga‐Manteiga et al . ). This disease is characterised by the enlargement of more than one peripheral or internal lymph node, with cytologic examination demonstrating necrosis, and a spectrum of suppurative/neutrophilic, pyogranulomatous or pure granulomatous inflammation.…”

“…, Fraga‐Manteiga et al . , Martens ). Mineral‐associated lymphadenopathy has also been described as an uncommon cause of sterile pyogranulomatous lymphadenitis in which deposition of complex mineral crystals in the peripheral lymph nodes initiates an intense granulomatous inflammation and lymphadenopathy (Day ).…”

“…, Fraga‐Manteiga et al . , Martens ). The onset of the disease can occur from a very early age, the youngest case reported being 4 weeks old (Scott & Miller ), although similar cases have been reported in adult dogs (Jeffers et al .…”