Idiopathic Sudden Hearing Loss and Disturbance of Iron Metabolism

Sun, Aihua; Wang, Zhengmin; Xiao, Shi-Zhi; Li, Zhaoji; Ding, Jincheng; Li, Jinying; Lingshan, Kong

doi:10.1159/000276264

Cited by 13 publications

(5 citation statements)

References 8 publications

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“…Auditory dysfunction has been associated with deficiencies of several micronutrients in humans (6)(7)(8)(9) and young growing animals (10)(11)(12)(13)(14). However, we found no studies in humans or experimental animals that specifically examined the role of nutrition in age-related hearing loss.…”

Section: Introductionmentioning

confidence: 85%

Age-related hearing loss, vitamin B-12, and folate in elderly women

Houston

Johnson

Nozza

et al. 1999

The American Journal of Clinical Nutrition

116

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Background: Hearing impairment is 1 of the 4 most prevalent chronic conditions in the elderly. However, the biological basis of age-related hearing loss is unknown. Objective: The objective was to test the hypothesis that agerelated hearing loss may be associated with poor vitamin B-12 and folate status. Design: A thorough audiometric assessment was conducted in 55 healthy women aged 60-71 y. Hearing function was determined by the average of pure-tone air conduction thresholds at 0.5, 1, 2, and 4 kHz and was categorized into 2 groups for logistic regression analyses: normal hearing (< 20 dB hearing level; n = 44) and impaired hearing (≥ 20 dB hearing level; n = 11). Results: Mean age was the same (65 y) for the normal hearing and impaired hearing groups. Pure-tone averages were inversely correlated with serum vitamin B-12 (r = Ϫ0.58, P = 0.0001) and red cell folate (r = Ϫ0.37, P = 0.01). Women with impaired hearing had 38% lower serum vitamin B-12 (236 compared with 380 pmol/L, respectively, P = 0.008) and 31% lower red cell folate (425 compared with 619 nmol/L, respectively, P = 0.02) than women with normal hearing. Among participants who did not take supplements containing vitamin B-12 or folate, women with impaired hearing had 48% lower serum vitamin B-12 (156 compared with 302 pmol/L, respectively, P = 0.0007) and 43% lower red cell folate (288 compared with 502 nmol/L, respectively, P = 0.001) than women with normal hearing. Conclusion: Poor vitamin B-12 and folate status may be associated with age-related auditory dysfunction.Am J Clin Nutr 1999;69:564-71.

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Section: Introductionmentioning

confidence: 85%

Age-related hearing loss, vitamin B-12, and folate in elderly women

Houston

Johnson

Nozza

et al. 1999

The American Journal of Clinical Nutrition

116

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“…Some researchers have described the association between ISSNHL and IDA, 4 , 5 with a recent American survey of adults indicating a significant relationship between IDA and SNHL with increased odds of 1.82. 6 A vascular mechanism has been proposed to explain the hearing loss due to IDA in that the cochlea is highly susceptible to ischemic damage, since only the labyrinthine artery supplies blood to this area.…”

Section: Discussionmentioning

confidence: 99%

Low-Frequency Sensorineural Hearing Loss Associated With Iron-Deficiency Anemia

et al. 2021

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Past studies have found an association between cochlear hydrops or early Meniere’s disease and acute low-frequency hearing loss (ALHL) without vertigo. However, its mechanism remains unclear in some ALHL cases. This report presents a case of ALHL associated with iron-deficiency anemia (IDA). The patient was a 49-year-old female who had previously been treated with betamethasone for sudden hearing loss in the right ear. Eight months later, the symptoms recurred and cochlear hydrops was diagnosed. Isosorbide and betamethasone were administered orally, and intravenous hydrocortisone tapering was added 1 week later, but these treatments were ineffective. At the same time and subsequently, iron sucrose was intravenously administered for IDA, and the patient’s hearing loss gradually resolved within 2 months. In view of the increase in serum hemoglobin levels after iron therapy, this might have been the most effective treatment in this case. The hearing loss could therefore be associated with the patient’s IDA.

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“…Roughly 360 million people around the world have some form of hearing loss and 32 million of these are children [1]. Dietary intake may play a role in the pathogenesis of many auditory disorders [2]. Deficiencies of several micronutrients have been associated with auditory dysfunction disorders in humans [3] and young growing animals [4].…”

Section: Introductionmentioning

confidence: 99%

A Survey of Vitamin Intake amongst Hearing and Hearing-Impaired Female Students in Saudi Arabia: A Pilot Study

Amin¹,

Maha²

2020

Int J Women's Health Wellness

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Background: Previous international research shows severe vitamin deficiencies in people with hearing loss. Hearing loss is improved for many people when vitamins such as A, B, C, D, E and K are replaced. Objective: To determine whether a dietary intake of vitamins linked to deafness were deficient among a group of 18-21 year-old hearing impaired and hearing Saudi Arabian female students. Design: This was a cross sectional study involving 64 hearing students and 42 hard of hearing female students aged 18-21 in a university in Saudi Arabia. Food intake was assessed by a food frequency questionnaire. Vitamin levels were calculated for each food and compared to the recommended daily allowance (RDA) for each group. Knowledge and understanding of vitamin deficiency was answered by face to face interviews. The study duration was one year from September 2010 to September 2011.

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Idiopathic Sudden Hearing Loss and Disturbance of Iron Metabolism

Cited by 13 publications

References 8 publications

Age-related hearing loss, vitamin B-12, and folate in elderly women

Age-related hearing loss, vitamin B-12, and folate in elderly women

Low-Frequency Sensorineural Hearing Loss Associated With Iron-Deficiency Anemia

A Survey of Vitamin Intake amongst Hearing and Hearing-Impaired Female Students in Saudi Arabia: A Pilot Study

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