Idiopathic thrombocytopenic purpura (ITP) and hyperthyroidism: An unusual but critical association for clinicians

Azar, Madona; Frates, Angela; Rajput, Vijay

doi:10.1002/jhm.312

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…Reports of simultaneous presentations of ITP and autoimmune thyroid disease are often encountered [16,17]. ITP may present itself earlier or at a significantly different time to the diagnosis of thyroid disorders.…”

Section: Discussionmentioning

confidence: 95%

Prevalence and Clinical Significance of Antithyroid Antibodies in Children with Immune Thrombocytopenic Purpura

Bay¹,

Coskun²,

Leblebisatan³

et al. 2013

Pediatric Hematology and Oncology

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We demonstrated that the thyroid-autoimmune-diseases-related autoantibodies are frequently found in childhood ITP. Although no recommendation is found in international guidelines regarding screening for thyroid autoantibodies in patients with ITP, in view of the high incidence of antithyroid antibodies and their potential negative effect on treatment response, screening these patients for such antibodies would be recommended.

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Section: Discussionmentioning

confidence: 95%

Prevalence and Clinical Significance of Antithyroid Antibodies in Children with Immune Thrombocytopenic Purpura

Bay¹,

Coskun²,

Leblebisatan³

et al. 2013

Pediatric Hematology and Oncology

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“…Possible mechanisms of thyrotoxicosis-induced thrombocytopenia include thyrotoxicosis induced activation of reticuloendothelial system, increased clearance of platelets by spleen and alteration of platelets aggregation. Restoration of PC after reverting back to euthyroidism is the rule [3].…”

Section: Discussionmentioning

confidence: 99%

Thrombocytopenia in a Patient with Graves’ Disease: An Uncommon Association of Two Common Autoimmune Diseases

Morshed¹,

Ma²,

Fariduddin³

et al. 2019

AJMCR

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We describe a 65-year-old male of Graves' disease with thyroid-associated orbitopathy who developed thrombocytopenia during the course of illness. Clinical features, temporal relationship with drugs and investigations supported the diagnosis of immune thrombocytoenic purpura. Several immunosuppressive drugs failed to improve thrombocytopenia. At last platelet count returned back to normal and remained stable with addition of dapsone and restoration of euthyroidism.

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“…The presentation of this association varies from case to case. It can present with a new onset of thrombocytopenia without life-threatening symptoms in a patient with preexisting hyperthyroidism, or it can present with a life-threatening thyrotoxic crisis which mimics sepsis in a known case of stable ITP [ 4 5 ]. In fact, studies show that autoimmune thrombocytopenia, in the course of thyroid disease, is far more prevalent than vice versa [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

The association of hyperthyroidism and immune thrombocytopenia: Are we still missing something?

Shekhda

2018

Tzu Chi Med J

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Though the American society of hematology Guidelines and British guidelines do not recommend screening of thyroid diseases in cases of immune thrombocytopenia (ITP), more than 160 cases of hyperthyroidism associated with ITP have been reported. Numerous case reports would suggest that patients with ITP and concurrent hyperthyroidism would respond to control of thyroid disease rather than the standard ITP treatment. Although this issue is still debatable, we report a case of a young female with a previous diagnosis of hyperthyroidism which was not well controlled, had presented with severe thrombocytopenia. Initially, all work-up had been done to find out the cause of thrombocytopenia. After all normal reports except deranged thyroid function tests, the patient was labeled as ITP and started on steroids. Even after a few months of steroid treatment, platelet counts had not improved. However, after starting antithyroid drugs, platelet counts had become normalized.

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Idiopathic thrombocytopenic purpura (ITP) and hyperthyroidism: An unusual but critical association for clinicians

Cited by 4 publications

References 10 publications

Prevalence and Clinical Significance of Antithyroid Antibodies in Children with Immune Thrombocytopenic Purpura

Prevalence and Clinical Significance of Antithyroid Antibodies in Children with Immune Thrombocytopenic Purpura

Thrombocytopenia in a Patient with Graves’ Disease: An Uncommon Association of Two Common Autoimmune Diseases

The association of hyperthyroidism and immune thrombocytopenia: Are we still missing something?

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