Idiopathic thrombocytopenic purpura with normal platelet survival time

Abstract

SYNOPSIS Platelet survival has been measured in 16 patients with idiopathic thrombocytopenic purpura. Of this group, three patients had a normal result and surface counting did not show high spienic uptake. The clinical features of these patients are described. These patients have remained well for several years without treatment.

Idiopathic Thrombocytopenic Purpura (ITP): Clinical and Immunologic Considerations

“…By means of the modern technic of platelet labeling with radioactive isotopes, these findings have been amply verified [5,66,71,124,125,134,136] and have clearly established that platelet survival is markedly shortened in ITP. However, a few perplexing cases of "ITP" with apparently normal platelet survival have been reported [8,31,49]. On the other hand, a normal platelet count after splenectomy does not exclude the presence of the "antiplatelet factor" [73].…”