Idiopathic Ventricular Fibrillation

Visser, Marloes; Heijden, Jeroen F. van der; Doevendans, Pieter A.; Loh, Peter; Wilde, Arthur A.M.; Hassink, Rutger J.

doi:10.1161/circep.115.003817

Cited by 82 publications

(41 citation statements)

References 82 publications

(70 reference statements)

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“…1 We also consider ER and ER syndrome as a separate disease entity that is distinct from IVF; therefore, we excluded all patients diagnosed with ER syndrome since 2013. 21 This partly explains the lack of ER in our IVF cohort, with the addition that ER was also simply not present in our cohort as re-evaluation of all available ECGs at 1, 5, and 10 years of follow-up did not show signs of ER.…”

Section: Discussionmentioning

confidence: 63%

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Long-Term Outcome of Patients Initially Diagnosed With Idiopathic Ventricular Fibrillation

Visser

Heijden

Smagt

et al. 2016

Circ: Arrhythmia and Electrophysiology

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Background— Idiopathic ventricular fibrillation (IVF) is a rare cause of sudden cardiac arrest. Limited data are available on the long-term outcome of IVF patients. Methods and Results— In this retrospective cohort study, 107 consecutive patients with an initial diagnosis of IVF were analyzed (age at index event 40.4 years, 60% male). Missing diagnostic data were acquired during follow-up, including genetic testing, to exclude underlying disease. A specific diagnosis was revealed in 22 of 107 patients (21%) during a median follow-up of 10.2 years. Mortality rate was 9% in IVF patients (8/85). Appropriate implantable cardioverter–defibrillator therapy was delivered in 23 patients (29%) of 78 IVF patients with an implantable cardioverter–defibrillator, with a median of 3 appropriate shocks per patient. Conclusions— One fifth of the patients initially diagnosed with IVF reveal a specific diagnosis during long-term follow-up. Additional diagnostic testing, including genetic testing, contributes to the detection of specific diseases. The recurrence rate of ventricular arrhythmias in IVF patients is high. Our data show the importance of thorough follow-up and reassessment of diagnosis in IVF patients.

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Section: Discussionmentioning

confidence: 63%

“…21,22 Although an underlying cause is detected in these patients, the exact pathophysiological mechanism is unknown, and clinical abnormalities are absent. Therefore, DPP6 is still regarded as IVF.…”

Section: Specific Diagnoses During Follow-upmentioning

confidence: 99%

Long-Term Outcome of Patients Initially Diagnosed With Idiopathic Ventricular Fibrillation

Visser

Heijden

Smagt

et al. 2016

Circ: Arrhythmia and Electrophysiology

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“…Limited data are available on the natural history of idiopathic ventricular fibrillation, including identification of putative pathogenic mutations, and management of patients with idiopathic ventricular fibrillation and their family members [2, 4]. …”

Section: Introductionmentioning

confidence: 99%

“…We proposed a flowchart to standardise diagnostic testing in patients with idiopathic ventricular fibrillation [2]. Routine testing comprises electrocardiogram (ECG), blood chemistry (cardiac enzymes, electrolytes, and thyroid function), toxicology screening, chest X‑ray, echocardiography, exercise testing, Holter or telemetry monitoring, coronary angiography with or without ventriculography, and magnetic resonance imaging.…”

Section: Introductionmentioning

confidence: 99%

“…When these tests reveal no abnormalities, provocation tests for Brugada syndrome (ajmaline/flecainide test) and coronary artery spasm (ergonovine/acetylcholine test) are recommended. Additional testing, such as endomyocardial biopsy, electrophysiological studies and genetic testing, is under debate, as their diagnostic value in idiopathic ventricular fibrillation is uncertain [2]. …”

Section: Introductionmentioning

confidence: 99%

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Life-long tailoring of diagnosis and management of patients with idiopathic ventricular fibrillation—future perspectives in research

et al. 2018

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The diagnosis and management of idiopathic ventricular fibrillation is challenging, as it requires extensive diagnostic testing and offers few curative options due to unknown underlying disease. The resulting population is a heterogeneous group of patients with a largely unknown natural history. Structural patient characterisation, follow-up and innovations in diagnostic testing can improve our understanding of the disease mechanisms of idiopathic ventricular fibrillation, detect underlying disease during follow-up and aid in therapeutic management. Recently, initiatives have been launched in the Netherlands to investigate the role of high-resolution non-invasive electrocardiographic imaging and genetic and familial screening in idiopathic ventricular fibrillation.

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Ventricular Arrhythmias

2022

Practical Cardiovascular Medicine

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Idiopathic Ventricular Fibrillation

Cited by 82 publications

References 82 publications

Long-Term Outcome of Patients Initially Diagnosed With Idiopathic Ventricular Fibrillation

Long-Term Outcome of Patients Initially Diagnosed With Idiopathic Ventricular Fibrillation

Life-long tailoring of diagnosis and management of patients with idiopathic ventricular fibrillation—future perspectives in research

Ventricular Arrhythmias

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