Idiosyncratic organization of cortical networks in autism spectrum disorder

Nunes, Adonay S.; Peatfield, Nicholas; Vakorin, Vasily A.; Doesburg, Sam M.

doi:10.1016/j.neuroimage.2018.01.022

Cited by 89 publications

(76 citation statements)

References 46 publications

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“…In other words, the more distinct is the shape of the curvature in ASD groups from that of the typical female trajectory the more severe the ASD symptomatology. This result is partially congruent with recent studies on ASD idiosyncrasy (Hahamy et al, ; Nunes et al, ; Vakorin et al, ). Although these prior studies demonstrated that ASD symptomatology increases with deviation from typical pattern, they did not investigate the impact of sex differences in this association.…”

Section: Discussionsupporting

confidence: 91%

“…Our approach for investigating potential associations between trajectories and ADOS scores was based on recent findings regarding slowing of cortical thinning in individuals with ASD (Nunes, Peatfield, Vakorin, & Doesburg, under review). Specifically, the study demonstrated that the shape of developmental curvature is related to ASD symptomatology.…”

Section: Methodsmentioning

confidence: 99%

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Extreme male developmental trajectories of homotopic brain connectivity in autism

Kozhemiako

Vakorin

Nunes

et al. 2018

Human Brain Mapping

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It has been proposed that autism spectrum disorder (ASD) may be characterized by an extreme male brain (EMB) pattern of brain development. Here, we performed the first investigation of how age‐related changes in functional brain connectivity may be expressed differently in females and males with ASD. We analyzed resting‐state functional magnetic resonance imaging data of 107 typically developing (TD) females, 114 TD males, 104 females, and 115 males with ASD (6–26 years) from the autism brain imaging data exchange repository. We explored how interhemispheric homotopic connectivity and its maturational curvatures change across groups. Differences between ASD and TD and between females and males with ASD were observed for the rate of changes in connectivity in the absence of overall differences in connectivity. The largest portion of variance in age‐related changes in connectivity was described through similarities between TD males, ASD males, and ASD females, in contrast to TD females. We found that shape of developmental curvature is associated with symptomatology in both males and females with ASD. We demonstrated that females and males with ASD tended to follow the male pattern of developmental changes in interhemispheric connectivity, supporting the EMB theory of ASD.

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Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Extreme male developmental trajectories of homotopic brain connectivity in autism

Kozhemiako

Vakorin

Nunes

et al. 2018

Human Brain Mapping

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“…Secondly, our results were complimented by measures of ITC, which showed reduced phase consistency in the autistic group from 0.5-1.0s poststimulus onset ( Figure 5) that was most pronounced in right A1. Reduced phase consistency may reflect more idiosyncratic neural responses in autism [54,55], as previously reported for evoked data [56]. Importantly, measures of ITC are normalised by amplitude and more robust to data with lower signal-to-noise ratios [23].…”

Section: Auditory Steady State Responses (Assr) In Autismmentioning

confidence: 71%

Reduced Auditory Steady State Responses in Autism Spectrum Disorder

Seymour

Rippon

Gooding-Williams

et al. 2019

Preprint

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Background: Auditory steady state responses (ASSRs) are elicited by clicktrains or amplitude-modulated tones, which entrain auditory cortex at their specific modulation rate.Previous research has reported reductions in ASSRs at 40Hz for autism spectrum disorder (ASD) participants and first-degree relatives of people diagnosed with ASD [1,2].Methods: Using a 1.5s-long auditory clicktrain stimulus, designed to elicit an ASSR at 40Hz, this study attempted to replicate and extend these findings. Magnetencephalography (MEG) data were collected from 18 adolescent ASD participants and 18 typically developing controls. Results:The ASSR localised to bilateral primary auditory regions. Regions of interest were thus defined in left and right primary auditory cortex (A1). While the transient gamma-band response (tGBR) from 0-0.3s following presentation of the clicktrain stimulus was not different between groups, for either left or right A1, the ASD group had reduced oscillatory power at 40Hz from 0.3 to 1.5s post-stimulus onset, for both left and right A1. Additionally, the ASD group had reduced inter-trial coherence (phase consistency over trials) at 40Hz from 0.5-1.0s for right A1 and 0.9-1.1s for left A1. Limitations:In this study, we did not conduct a clinical autism assessment (e.g. the ADOS), and therefore it remains unclear whether ASSR power and/or ITC are associated with the clinical symptoms of ASD. Conclusion:Overall, our results support a specific reduction in ASSR oscillatory power and inter-trial coherence in ASD, rather than a generalised deficit in gamma-band responses. We argue that this could reflect a developmentally relevant reduction in non-linear neural processing.

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“…Heterogeneity in ASD is a well‐established phenomenon, and exists at all levels of investigation ranging from genes to brains to behavior (Tordjman et al, ). Indeed, several fMRI studies have found heterogeneous patterns of functional activity and connectivity within individuals with ASD (Byrge, Dubois, Tyszka, Adolphs, & Kennedy, ; Dickie et al, ; Hahamy et al, ; Nunes, Peatfield, Vakorin, & Doesburg, ). Using case–control comparisons and searching for common alterations exhibited across the group can easily obscure nonshared, heterogeneous patterns of differences across individuals.…”

Section: Discussionmentioning

confidence: 99%

Nonreplication of functional connectivity differences in autism spectrum disorder across multiple sites and denoising strategies

Byrge

Kennedy

2020

Human Brain Mapping

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A rapidly growing number of studies on autism spectrum disorder (ASD) have used resting‐state fMRI to identify alterations of functional connectivity, with the hope of identifying clinical biomarkers or underlying neural mechanisms. However, results have been largely inconsistent across studies, and there remains a pressing need to determine the primary factors influencing replicability. Here, we used resting‐state fMRI data from the Autism Brain Imaging Data Exchange to investigate two potential factors: denoising strategy and data site (which differ in terms of sample, data acquisition, etc.). We examined the similarity of both group‐averaged functional connectomes and group‐level differences (ASD vs. control) across 33 denoising pipelines and four independently‐acquired datasets. The group‐averaged connectomes were highly consistent across pipelines (r = 0.92 ± 0.06) and sites (r = 0.88 ± 0.02). However, the group differences, while still consistent within site across pipelines (r = 0.76 ± 0.12), were highly inconsistent across sites regardless of choice of denoising strategies (r = 0.07 ± 0.04), suggesting lack of replication may be strongly influenced by site and/or cohort differences. Across‐site similarity remained low even when considering the data at a large‐scale network level or when considering only the most significant edges. We further show through an extensive literature survey that the parameters chosen in the current study (i.e., sample size, age range, preprocessing methods) are quite representative of the published literature. These results highlight the importance of examining replicability in future studies of ASD, and, more generally, call for extra caution when interpreting alterations in functional connectivity across groups of individuals.

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Idiosyncratic organization of cortical networks in autism spectrum disorder

Cited by 89 publications

References 46 publications

Extreme male developmental trajectories of homotopic brain connectivity in autism

Extreme male developmental trajectories of homotopic brain connectivity in autism

Reduced Auditory Steady State Responses in Autism Spectrum Disorder

Nonreplication of functional connectivity differences in autism spectrum disorder across multiple sites and denoising strategies

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