Idiotypic Regulation in Immune Networks

Urbain, Jacques; Wuilmart, Christian; Cazenave, Pierre-André

doi:10.1007/978-1-4684-3917-5_4

Cited by 108 publications

(36 citation statements)

References 143 publications

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“…Immunosuppression would teleologically suppress the inhibitor of the autoregulator, i.e. result in a net suppressive effect consistent with a network hypothesis (29)(30)(31).…”

Section: Discussionsupporting

confidence: 75%

Factors affecting the autologous mixed lymphocyte reaction in kidney transplantation.

et al. 1983

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A B S T R A C T In long-term well adapted kidney transplant recipients we have found a close correlation between the T helper (TH):T suppressor/cytotoxic (Ts/c) subset ratios and the presence of T cells that respond in the autologous mixed lymphocyte reaction (AMLR). In 21 recipients with T cell E rosette levels ranging between 53 and 86% and TH:TS/c ratios between 0.15 to 2.10, ratios of >0.8 correlated with AMLR responses (13/13), and ratios of <0.8 with AMLR nonreactivity (7/7). By contrast, the allogeneic MLR showed no apparent correlation with the TH:Ts/c ratios or with the AMLR pre-or postoperatively. It was found that the AMLR in 22 of 23 normal individuals was markedly inhibited by autologous T cells obtained from peripheral blood lymphocytes, exposed to 3,000 rad (Tx) and added as a third component to the cultures. In contrast, 13 of 13 kidney transplant recipients failed to exhibit this Tx AMLR inhibitory cell population. The "naturally occurring" T inhibitory cells, fractionated by an affinity column chromatography procedure into x-irradiated TH and Ts/c subsets, inhibited the AMLR to the same extent as unseparated Tx cells. In cell interchange studies performed in four of five HLA identical donor-recipient pairs the Tx cells of the (normal) donor inhibited the recipient AMLR (immunosuppressed), but recipient Tx cells failed to inhibit the donor AMLR. Finally T cells, primed in AMLR and allogeneic MLR for 10 d were tested for AMLR or allogeneic MLR inhibitory activity. Allogeneic MLR primed x-irradiated cells, inhibited both the AMLR and allogeneic MLR while AMLR x-irradiated primed cells inhibited neither reaction. The Tx AMLR inhib-

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“…Immunosuppression would teleologically suppress the inhibitor of the autoregulator, i.e. result in a net suppressive effect consistent with a network hypothesis (29)(30)(31).…”

Section: Discussionsupporting

confidence: 75%

Factors affecting the autologous mixed lymphocyte reaction in kidney transplantation.

et al. 1983

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“…A final consideration pertains to regulation via idiotypes [45]. Our results predict that B lymphocytes would rarely be in a position to induce cytotoxic T cells against self idiotypes simply because help is needed.…”

Section: Discussionmentioning

confidence: 89%

CD8 T cell priming by B lymphocytes is CD4 help dependent

Castiglioni¹,

Gerloni²,

Cortez-Gonzalez³

et al. 2005

Eur J Immunol

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While it is generally accepted that B lymphocytes can present antigen and activate CD4 T cells, priming of CD8 T cells by B lymphocytes remains controversial. Recently, we showed that mice injected with genetically programmed B lymphocytes generate antigen specific CD4 and CD8 T cell responses in vivo that could also be induced in mice lacking functional dendritic cells. To gain further insights into the requirements for T cell priming by antigen-presenting B lymphocytes, in vitro experiments were performed using ovalbumin (OVA) and OVA-specific TCR-transgenic CD4 and CD8 T cells. We found that while B lymphocytes can directly prime CD4 T cells, the activation of CD8 T cells requires T cell help. Transfer experiments show that help can either be contact dependent or be mediated by soluble factors in the supernatants of activated OVAspecific CD4 T cells. Furthermore, the effect of activated CD4 T cells can be replaced by soluble recombinant IL-4. Collectively, the data show the existence of different requirements for priming of CD4 and CD8 T cells and point to the previously unappreciated fact that the induction of CD8 T cell responses by B lymphocytes requires T cell help.

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“…Numerous studies have shown that idiotype-antiidiotype interactions can result in either suppression or stimulation of an immune response (2)(3)(4). When antigen is presented to the immune system, immunoglobulin reactive to antigen is produced (Ab1).…”

Section: Introductionmentioning

confidence: 99%

Antiidiotypic antibody vaccine in murine Schistosomiasis mansoni comprising the internal image of antigen.

Kresina¹,

Olds²

1989

J. Clin. Invest.

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This study presents the characterization of an experimental immunotherapeutic approach for schistosomiasis utilizing antiidiotypic antibodies. Antiidiotype (31-3B6) was generated in rabbits using a protective murine monoclonal antibody 31-3B6 which recognizes a 68,000-D molecular mass glycoprotein present in extracts of Schistosomiasis mansoni adult worm homogenetics. Immunization of mice with antiidiotype (31-3B6) before S. mansoni cercariae infection resulted in protection levels ranging from 16 to 41% depending on the route of administration of antiidiotypic antibody and the use of adjuvant. Levels of protection as high as 25% could be obtained with a single injection of antiidiotype (31-3B6) without the use of adjuvant. Animals noted to be resistant to infection with S. mansoni cercariae were also noted to exhibit a humoral immune response that bound components of S. mansoni adult worm homogenetics. This induced antiantigen immune response was shown to bind to the surface of S. mansoni schistosoma by indirect immunofluorescence. Further characterization of the induced antiantigen response showed that a portion (3-32%) of the induced humoral immune response portrayed the binding specificities of the murine monoclonal antibody 31-3B6. The data indicate that antiidiotype antibodies generated utilizing defined monoclonal antibodies can act as surrogate antigens in the protection of infection in schistosomiasis.

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Idiotypic Regulation in Immune Networks

Cited by 108 publications

References 143 publications

Factors affecting the autologous mixed lymphocyte reaction in kidney transplantation.

Factors affecting the autologous mixed lymphocyte reaction in kidney transplantation.

CD8 T cell priming by B lymphocytes is CD4 help dependent

Antiidiotypic antibody vaccine in murine Schistosomiasis mansoni comprising the internal image of antigen.

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