Idiotypic vaccines and infectious diseases

Hiernaux, Jean

doi:10.1128/iai.56.6.1407-1413.1988

Cited by 63 publications

(16 citation statements)

References 69 publications

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“…Furthermore the anti-idiotypic antibodies were induced in BALB/c mice against MoAbs of BALB/c mice origin [17], So we conclude that with the NI-EIA antiidiotypic antibodies are determined against all or a part ofthe idiotypic determinants (idiotopes) of the SFV-neutralizing antibodies. Monoclonal anti-idiotypic antibodies, especially those (Ab2/J) carrying the internal image (paratope) of the antigen (epitope), are of interest as potential vaccines against pathogenic micro-organisms [6,13,15,20], The anti-idiotypic sera described in this paper abrogate the neutralizing capacity of SFV-specific MoAbs, This could be due to Ab^fi anti-idiotypic antibodies which bind to the antigen binding site (paratope). However, very likely other anti-idiotypic antibodies (e,g, Ab2a) inhibit neutralization by steric hindrance or even by mere aggregation of neutralizing MoAbs [19], The observation that anti-idiotypic sera inhibit specifically the neutralization ofa virus is not a unique finding, Gheuens et al [12] have described that mouse measles haemagglutinin-specific MoAbs are inhibited in their neutralizing activity by mouse anti-idiotypic serum as indicated by diminished neutralization of measles virus in a plaque reduction test.…”

Section: Discussionmentioning

confidence: 99%

Blocking by Anti‐Idiotypic Antibodies of Monoclonal Antibody‐Mediated Protection Against Lethal Semliki Forest Virus in Mice

Oosterlaken¹,

Harmsen²,

Kraaijeveld³

et al. 1990

Scand J Immunol

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Semliki Forest virus-(SEV) neutralizing monoclonal antibodies (MoAbs), produced after fusion of spleen cells from BALB/c mice and myeloma cell line P3-X63-AG8. 653 or SP2/0, were used for anti-idiotypic immunization of female BALB/c mice. Two intracutaneous immunizations (2 x 40 micrograms per animal), 3 weeks apart, with keyhole limpet haemocyanin-conjugated MoAbs mixed with the saponin Quil A were sufficient to induce high levels of anti-idiotypic antibodies in the circulation of these mice with the capacity to block specifically in vitro MoAb-mediated virus neutralization. Anti-idiotypic antibodies against SFV-neutralizing MoAbs, either passively transferred or actively acquired by immunization, are also able to abrogate (specifically) passive immunity, mediated by critical protective doses of MoAb, in mice against infection with a lethal strain of SFV. Furthermore we confirmed by intervention with anti-idiotypic serum in vivo that an SFV-neutralizing MoAb exerts its greatest protective effect during the first 2 days of infection.

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Section: Discussionmentioning

confidence: 99%

Blocking by Anti‐Idiotypic Antibodies of Monoclonal Antibody‐Mediated Protection Against Lethal Semliki Forest Virus in Mice

Oosterlaken¹,

Harmsen²,

Kraaijeveld³

et al. 1990

Scand J Immunol

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“…Another difference between the anti-id caries immunization (11) and our present data is the fact that both the rat antistreptococcal id Abs and the corresponding rabbit anti-id Abs were polyclonal and hence much more complex and less characterized, whereas both our id MAbl and anti-id MAb2 were well-defined MAbs. Furthermore, the presence of an internal image in the antistreptococcal anti-id Abs was deduced only from the fact that these injected Ab2's induced some protection, both by Since several authors agree that Ab2a and Ab2-y anti-id Abs can also immunize, without, however, providing details on protection (10,38), the question of whether the polyclonal anti-id Ab2s in that study (11) really contained some Ab2,B remains unanswered. Finally, purification and characterization of the rat antistreptococcal Ab3 was not examined in that study (11), whereas we demonstrated, by several tests, a large similarity of reaction between the rat serum anti-CT Ab3 and mouse MAbl, as expected from the id-anti-id network theory.…”

Section: Resultsmentioning

confidence: 98%

Protection of rat intestine against cholera toxin challenge by monoclonal anti-idiotypic antibody immunization via enteral and parenteral routes

1991

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A mouse monoclonal anti-idiotypic (anti-id) immunoglobulin M (IgM) antibody, called MAb2, was raised against a mouse monoclonal anti-cholera toxin (anti-CT) antibody (MAbl). The MAb2 was shown, by competition with CT for MAbl, to bear the internal image of an epitope of CT. MAb2 immunization of rats was performed via the intraperitoneal, intragastric, and intrajejunal routes and compared with immunization of rats with either a control, isotype-and allotype-matched MAb or with CT via the same routes. Both serum IgG and bile IgA anti-CT Ab3's were detected by enzyme-linked immunosorbent assay in anti-id MAb2immunized rats, although their titers were lower than those in CT-immunized rats. No anti-CT antibodies were detected in sera and bile of rats immunized with the control MAb. When tested for degree of gut protection against a CT challenge, rats immunized with MAb2 by the intrajejunal route showed a rather high degree of protection, which was only slightly lower than that of rats immunized with CT via the same route; all rats but one immunized with the control MAb were unprotected. There was, however, no correlation between serum or bile anti-CT titers and degree of gut protection in MAb2-immunized rats. Their serum anti-CT Ab3's were purified by adsorption and elution from a CT immunosorbent and resembled anti-CT MAbl in their unique reactivity with MAb2. This constitutes to our knowledge the second report of protection against a pathogen by anti-id immunization via the enteric route.

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“…The development of antiviral autoantibodies that bind target cell molecules, in addition to the appearance of anti-Ids that mimic crucial target cell antigens, could be damaging to the host. The triggering of antiviral antibody by anti-Id pulsed B cells or splenocytes, while being fundamentally a protective response, can be detrimental to possible cross-reactivity against myocyte antigen(s), the generation of auto-anti-Ids with mimicry for virus or tissue determinants, and the possibility of triggering other immunoregulatory cells to react against self-components (1,4,6,7).…”

Section: Discussionmentioning

confidence: 99%

Adoptively transferred anti-idiotype pulsed B cells mediate autoimmune myocarditis

Paque

Miller

1992

Infect Immun

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Syngeneic mice receiving adoptively transferred enriched B cells or splenocytes pulsed in vitro with polyclonal anti-idiotypic antibodies (anti-Ids) against anti-CVB3 virus antibodies developed coxsackievirus B3 antigenbinding and virus-neutralizing antibodies during a 30-day period, in addition to overt expression of autoimmune myocarditis. Adoptive transfer of anti-Id pulsed T cells resulted in delayed appearance and transient expression of antiviral antibodies, and antiviral antibodies were marginal to absent in syngeneic animals receiving anti-Id pulsed macrophage populations. Proliferation analysis of recipient splenocytes indicated lack of proliferative capacity in response to monoclonal or polyclonal anti-Ids and only marginal proliferative capacity in response to coxsackievirus B3 virus antigen(s). In vitro assessment of delayed hypersensitivity in recipient animals demonstrated some specific immunity to anti-Ids in recipients receiving splenocytes or T cells. Anti-Ids expressing mimicry for heart-associated and/or viral antigen(s) interacting with B cells or other accessory cells suggest an autoantibody or anti-Id triggering of B-cell-mediated mechanisms involved in the development of myocarditis.

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Idiotypic vaccines and infectious diseases

Cited by 63 publications

References 69 publications

Blocking by Anti‐Idiotypic Antibodies of Monoclonal Antibody‐Mediated Protection Against Lethal Semliki Forest Virus in Mice

Blocking by Anti‐Idiotypic Antibodies of Monoclonal Antibody‐Mediated Protection Against Lethal Semliki Forest Virus in Mice

Protection of rat intestine against cholera toxin challenge by monoclonal anti-idiotypic antibody immunization via enteral and parenteral routes

Adoptively transferred anti-idiotype pulsed B cells mediate autoimmune myocarditis

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