IDM release behavior and surface characteristics of the novel Cu/IDM/LDPE nanocomposite for intrauterine device

Yang, Zhihong; Xie, Changsheng; Xiang, Hua; Feng, Jinqing; Xia, Xianping; Cai, Shuizhou

doi:10.1016/j.colsurfb.2008.11.027

Cited by 9 publications

(7 citation statements)

References 14 publications

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“…T‐shaped copper intrauterine devices (Cu‐IUDs) are a form of reversible contraception for birth control, usually supported by a T‐shaped plastic scaffold of PE composites. The contraceptive effect of such devices depends on the position of the Cu‐IUD in the uterus .…”

Section: Introductionmentioning

confidence: 99%

Preparation, characterization, and properties of modified barium sulfate nanoparticles/polyethylene nanocomposites as T‐shaped copper intrauterine devices

Cao

Zhang

Chen

et al. 2014

J of Applied Polymer Sci

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To improve the mechanical properties and shelf‐life of barium sulfate nanoparticles (BaSO4‐NPs)/polyethylene (PE) composites, which are used as the scaffold of T‐shaped copper intrauterine devices (Cu‐IUDs) in the clinic, an Al coupling agent was used to modify BaSO4‐NPs. The influence of the Al coupling agent on the microstructures, properties, and shelf‐life of the nanocomposites were investigated. The results showed that: (1) a chemical reaction occurred between the Al coupling agent and the hydroxyl groups adsorbed by BaSO4‐NPs. (2) BaSO4‐NPs modified by the Al coupling agent dispersed in the PE matrix were much better than unmodified NPs. The interface bonding between modified NPs and the PE matrix was better than unmodified NPs. (3) the maximum tensile strength of nanocomposites containing modified NPs was 11.87 MPa, flexural strength was 6.61 MPa, and the elongation rate was 66.78%. (4) After an accelerated aging experiment, the tensile strength of the nanocomposites only decreased 5–15%. All of these results indicate that m‐BaSO4‐NPs/PE nanocomposites are more clinically useful than unmodified nanocomposites. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40393.

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Section: Introductionmentioning

confidence: 99%

Preparation, characterization, and properties of modified barium sulfate nanoparticles/polyethylene nanocomposites as T‐shaped copper intrauterine devices

Cao

Zhang

Chen

et al. 2014

J of Applied Polymer Sci

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“…Its inhibitory action was progressively lost over 14 days. Therefore, purine-coated IUDs started providing contraception 2 weeks after placement [159].…”

Section: Future Non-contraceptive Benefitsmentioning

confidence: 99%

“…These studies showed that indomethacin plasma levels peaked 1 h after placement and had a rapid decline phase for 100 h. Uterine tissue levels are higher than plasma levels and remain high for longer [162]. A new material with copper, indomethacin and low-density polyethylene nanocomposite has also been investigated, blending these approaches [159].…”

Section: Future Non-contraceptive Benefitsmentioning

confidence: 99%

New frontiers in female contraception (and male condoms): 2012

Nelson

2012

Expert Opinion on Investigational Drugs

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The goal of being planned and prepared for pregnancies is still only an abstract concept. Significant barriers to success from traditional sources (ambivalence, cultural and societal beliefs, the status of women, poverty) persist and are now joined by many other emerging structural problems. The consolidation of pharmaceutical companies reduces competition. The loss of profitability for contraceptives due to short-lasting patents, growing demand for generics and growing challenges from product liability reduce incentives for innovation. Healthcare reform in the US may further discourage new product development. However, new advances may still be possible from small start-up companies, philanthropic foundations and governmental research efforts. Other advances may be made by providing contraception in innovative ways and in the techniques we use to motivate patients to be more successful contraceptors.

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“…The novel nano-Cu/LDPE IUD consists of high-quality copper nanoparticles and LDPE powders, synthesized by heating and evaporation methods [6]. Previous studies on this novel composite IUD, including material characteristics [7], [8], [9], [10], [11], corrosion behavior [6], [12], contraceptive efficacy and clinical performance [13], antifertility effectiveness and influence on the endometrial environment [14], [15], it is indicated that the nano-Cu/LDPE composites could greatly improve the performance of IUDs.…”

Section: Introductionmentioning

confidence: 99%

Biological Evaluation of the Copper/Low-density Polyethylene Nanocomposite Intrauterine Device

Hou

et al. 2013

PLoS ONE

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Devices and materials intended for clinical applications as medical and implant devices should be evaluated to determine their biocompatibility in physiological systems. This article presents results from cytotoxicity assay of L929 mouse fibroblasts culture, tests for skin irritation, intracutaneous reactivity and sensitization, and material implantation tests for the novel copper/low-density polyethylene nanocomposite intrauterine device (nano-Cu/LDPE IUD) with potential for future clinical utilization. Cytotoxicity test in vitro was conducted to evaluate the change in morphology, growth and proliferation of cultured L929 mouse fibroblasts, which in vivo examination for skin irritation (n = 6) and intracutaneous reactivity (n = 6) were carried out to explore the irritant behavior in New Zealand White rabbits. Skin sensitization was implemented to evaluate the potential skin sensitizing in Hartley guinea pigs (n = 35). The materials were implanted into the spinal muscle of rabbits (n = 9). The cytotoxicity grade of the nano-Cu/LDPE IUD was 0–1, suggested that the composite was nontoxic or mildly cytotoxic; no irritation reaction and skin sensitization were identified in any animals of specific extracts prepared from the material under test; similarly to the control sides, the inflammatory reaction was observed in the rabbits living tissue of the implanted material in intramuscular implantation assay. They indicated that the novel composite intrauterine device presented potential for this type of application because they meet the requirements of the standard practices recommended for evaluating the biological reactivity. The nano-Cu/LDPE IUD has good biocompatibility, which is biologically safe for the clinical research as a novel contraceptive device.

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IDM release behavior and surface characteristics of the novel Cu/IDM/LDPE nanocomposite for intrauterine device

Cited by 9 publications

References 14 publications

Preparation, characterization, and properties of modified barium sulfate nanoparticles/polyethylene nanocomposites as T‐shaped copper intrauterine devices

Preparation, characterization, and properties of modified barium sulfate nanoparticles/polyethylene nanocomposites as T‐shaped copper intrauterine devices

New frontiers in female contraception (and male condoms): 2012

Biological Evaluation of the Copper/Low-density Polyethylene Nanocomposite Intrauterine Device

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