If I had...Severe rheumatoid arthritis.

McConkey, B

doi:10.1136/bmj.1.6122.1265

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Sulphasalazine: a Joint Effort1

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1981

2008

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Cited by 2 publications

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“…It was only after McConkey's group in Birmingham published their positive results in 1978 and 1980 23,24 that interest was rekindled. Such was his conviction that Brian McConkey was happy to pre‐empt the second study in his hypothetical article on the treatment of RA, which appeared in 1978 25 …”

Section: Sulphasalazine: a Joint Effortmentioning

confidence: 99%

Stopping the rot: the stories behind methotrexate, sulphasalazine and hydroxychloroquine

2008

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Untreated rheumatoid arthritis (RA) has devastating effects on joint structure, function and quality of life. Treatment has improved over the last few decades as the emphasis has switched from empiric symptomatic treatment with non‐steroidal anti‐inflammatory drugs to early introduction of disease‐modifying anti‐rheumatic drugs (DMARDs), and in severe disease, biological DMARDs. We review the history of methotrexate, sulphasalazine and hydroxychloroquine and reflect on how individual studies, world events and the discovery of cortisone may have ‘robbed’ a generation of RA patients of the treatments still used today – in particular methotrexate and sulphasalazine.

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Section: Sulphasalazine: a Joint Effortmentioning

confidence: 99%