Ifenprodil for prolonged spinal blockades of motor function and nociception in rats

Abstract

The resulting data demonstrated that ifenprodil produces a dose-dependent local anesthetic effect in spinal anesthesia. Ifenprodil shows a more sensory-selective duration of action over motor block, whereas the duration of anesthesia is significantly longer with ifenprodil than with bupivacaine.

Intrathecal pramoxine causes long-lasting spinal sensory and motor block in rats

“…The percentage of possible effect (% PE) indicated the magnitude of spinal block. [15,16] The percentage of maximum possible effect (%MPE) was the maximal block in the time course of spinal anaesthesia with drugs.…”