IFFS Surveillance 2016

Allan, Sonia; Balaban, Babak; Banker, Manish; Brinsden, Peter; Buster, John E.; Mocanu, Edgar; Pai, Hrishikesh; Roux, Paul le

doi:10.1097/grh.0000000000000001

Cited by 31 publications

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“…In some countries, oocyte donation is prohibited due to ethical issues and religious reasons (e.g., many Islamic countries). According to the survey of the International Federation of Infertility Society, 41 out of 215 countries do not allow oocyte donation ( 60 ). Moreover, some papers reported that oocyte donation resulted in high-risk pregnancies due to immune compatibility ( 61 , 62 ).…”

Section: The Implementation Of Ovarian Fragmentation and Akt Stimulat...mentioning

confidence: 99%

Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan

Kawamura

2021

Front. Reprod. Health

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Since the first baby was born after in vitro fertilization, the female infertility treatment has been well-developed, yielding successful outcomes. However, successful pregnancies for patients with premature ovarian insufficiency and diminished ovarian reserve are still difficult and diverse therapies have been suggested to improve the chances to have their genetically linked offspring. Recent studies demonstrated that the activation Akt pathway by using a phosphatase and tensin homolog enzyme inhibitor and a phosphatidylinositol-3 kinase stimulator can activate dormant primordial follicles in both mice and human ovaries. Subsequent researches suggested that the disruption of Hippo signaling pathway by ovarian fragmentation increased the expression of downstream growth factors and secondary follicle growth. Based on the combination of ovarian fragmentation and Akt stimulation, the in vitro activation (IVA) approach has resulted in successful follicle growth and live births in premature ovarian insufficiency patients. The approach with disruption of Hippo signaling only was also shown to be effective for treating poor ovarian responders with diminishing ovarian reserve, including advanced age women and cancer patients undergoing sterilizing treatments. This review aims to summarize the effectiveness of ovarian fragmentation and Akt stimulation on follicle growth and the potential of IVA in extending female fertile lifespan.

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Section: The Implementation Of Ovarian Fragmentation and Akt Stimulat...mentioning

confidence: 99%

Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan

Kawamura

2021

Front. Reprod. Health

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“…Maternal age, weight, genetic factors and artificial reproductive technologies (ART) are the main determinants of twinning and higher-order multiple rates [20]. To compensate overenthusiastic use of ART, several countries established regulations to reduce an uncontrolled origin of twin and higher-order multiple pregnancies caused by ART [21]. But even within Europe, legislation and practice vary considerably [22] resulting in rates of deliveries after ART between 0.54% in Malta and 4.1% in Denmark [23] which may impact the country-specific twinning rates.…”

Section: Meaning Of the Findingsmentioning

confidence: 99%

Challenges for better care based on the course of maternal body mass index, weight gain and multiple outcome in twin pregnancies: a population-based retrospective cohort study in Hessen/Germany within 15 years

Schubert

Timmesfeld

Noever³

et al. 2020

Arch Gynecol Obstet

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Introduction Studies on maternal weight, gestational weight gain and associated outcomes in twin pregnancies are scarce. Therefore, we analyzed these items in a large cohort. Methods Data from 10,603/13,725 total twin pregnancies from the perinatal database in Hessen, Germany between 2000 and 2015 were used after exclusion of incomplete or non-plausible data sets. The course of maternal and perinatal outcomes was evaluated by linear and logistic regression models. Results The rate of twin pregnancies increased from 1.5 to 1.9% (p < 0.00001). Mean maternal age and pre-pregnancy weight rose from 31.4 to 32.9 years and from 68.2 to 71.2 kg, respectively (p < 0.001). The rates of women with a body mass index ≥ 30 kg/m2 increased from 11.9 to 16.9% with a mean of 24.4–25.4 kg/m2 (p < 0.001). The overall increase of maternal weight/week was 568 g, the 25th quartile was 419, the 75th quartile 692 g/week. The total and secondary caesareans increased from 68.6 to 73.3% and from 20.6 to 39.8%, respectively (p < 0.001). Rates of birthweight < 1500 g and of preterm birth < 28 and from 28 to 33 + 6 weeks all increased (p < 0.01). No significant changes were observed in the rates of stillbirth, perinatal mortality and NICU admissions. Conclusion The global trend of the obesity epidemic is equally observed in German twin pregnancies. The increase of mean maternal weight and the calculated quartiles specific for twin pregnancies help to identify inadequate weight gain in twin gestations. Policy makers should be aware of future health risks specified for singleton and twin gestations.

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“…For example, in several countries including Algeria, Bahrain, Costa Rica, Egypt, Hong Kong, Jordan, Lebanon, Lithuania, Libya, Maldives, Oman, Pakistan, Philippines, Qatar, Saudi Arabia, Syria, Tajikistan, Tunisia, Turkey, United Arab Emirates, and Yemen, laws prohibit sperm donation. Moreover, egg donation is not available in countries such as China, Germany, Japan, Turkey and Saudi Arabia according to the International Federation of Fertility Societies ( 2016 ). Other countries have restrictions regarding the ability to use preimplantation genetic diagnosis (PGD), cryopreservation and other ART services ( Bayefsky, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Characteristics of patients seeking fertility care in a low-income setting

Tarrash,

Kuyoro,

Goldman

et al. 2024

JBRA

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Objective Patients face challenges accessing fertility treatment due to barriers such as financial burdens, delayed referral to Reproductive Endocrinologists (REI), low medical literacy, language barriers and numerous other health disparities. Medicaid in New York offers coverage for office visits, blood tests, hysterosalpingograms (HSGs), and pelvic ultrasounds for infertility. The aim of this study is to delineate the characteristics of this underserved population and determine their ability to complete the initial fertility workup. Methods This was a retrospective study of all patients seeking fertility care at a single resident/fellow REI clinic in New York from September 2020 - January 2022. Results During the study period, 87 patients (avg age = 35.2y) sought care at the resident/fellow clinic over 126 appointments. The majority of patients had Medicaid insurance and most primary languages spoken included English (70.1%), Spanish (21.8%), and Bengali (3.4%). Documented Race was comprised of mostly Other (46%), African American (21.8%), Asian (17.2%), and White (11.5%). The majority of patients completed a lab workup (70-80%). Fewer patients underwent a scheduled HSG (59.8%) and patients’ partners completed a semen analysis (SA) (27.6%). Overall, there was a significant difference in the ability to complete the initial infertility workup (lab tests vs. HSG vs. SA) across all groups regardless of age, insurance type, primary language spoken, race and ethnicity ( p <0.05). Conclusions Completing the fertility workup, particularly the male partner workup and imaging studies, can present challenges for underserved patients with infertility. Understanding which patient characteristics and societal factors restrict access to fertility care requires further investigation to improve access to fertility care in underserved communities.

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IFFS Surveillance 2016

Cited by 31 publications

References 0 publications

Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan

Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan

Challenges for better care based on the course of maternal body mass index, weight gain and multiple outcome in twin pregnancies: a population-based retrospective cohort study in Hessen/Germany within 15 years

Characteristics of patients seeking fertility care in a low-income setting

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