IFI16 plays a critical role in avian reovirus induced cellular immunosuppression and suppresses virus replication

Chengcheng, Zhang; Qingqing, Zhang; Xiaomiao, Hu; Wei, Li; Xiaorong, Zhang; Yantao, Wu

doi:10.1016/j.psj.2024.103506

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…Although less established, its connection to other clinical conditions such as runtingstunting syndrome, hepatitis, myocarditis, hydropericardium, malabsorption syndrome, and disorders of the respiratory, enteric, and central nervous systems, has been noted [4]. ARV infection is also linked to immunosuppression [5], likely due to lymphoid depletion in immune system organs and the induction of cell apoptosis [6][7][8]. When layer and breeder flocks are affected, decreases in egg production, fertility, and hatchability are noted, along with vertical transmission to offspring [4].…”

Section: Introductionmentioning

confidence: 99%

Reconstruction of Avian Reovirus History and Dispersal Patterns: A Phylodynamic Study

Franzo,

Tucciarone,

Faustini

et al. 2024

Viruses

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Avian reovirus (ARV) infection can cause significant losses to the poultry industry. Disease control has traditionally been attempted mainly through vaccination. However, the increase in clinical outbreaks in the last decades demonstrated the poor effectiveness of current vaccination approaches. The present study reconstructs the evolution and molecular epidemiology of different ARV genotypes using a phylodynamic approach, benefiting from a collection of more than one thousand sigma C (σC) sequences sampled over time at a worldwide level. ARVs’ origin was estimated to occur several centuries ago, largely predating the first clinical reports. The origins of all genotypes were inferred at least one century ago, and their emergence and rise reflect the intensification of the poultry industry. The introduction of vaccinations had only limited and transitory effects on viral circulation and further expansion was observed, particularly after the 1990s, likely because of the limited immunity and the suboptimal and patchy vaccination application. In parallel, strong selective pressures acted with different strengths and directionalities among genotypes, leading to the emergence of new variants. While preventing the spread of new variants with different phenotypic features would be pivotal, a phylogeographic analysis revealed an intricate network of viral migrations occurring even over long distances and reflecting well-established socio-economic relationships.

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Section: Introductionmentioning

confidence: 99%

Reconstruction of Avian Reovirus History and Dispersal Patterns: A Phylodynamic Study

Franzo,

Tucciarone,

Faustini

et al. 2024

Viruses

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Antiviral Effects of Avian Interferon-Stimulated Genes

He,

Zhang,

Zou

et al. 2024

Animals

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Interferons (IFNs) stimulate the expression of numerous IFN-stimulating genes via the Janus kinase-signal transducers and activators of the transcription (JAK-STAT) signaling pathway, which plays an important role in the host defense against viral infections. In mammals, including humans and mice, a substantial number of IFN-stimulated genes (ISGs) have been identified, and their molecular mechanisms have been elucidated. It is important to note that avian species are phylogenetically distant from mammals, resulting in distinct IFN-induced ISGs that may have different functions. At present, only a limited number of avian ISGs have been identified. In this review, we summarized the identified avian ISGs and their antiviral activities. As gene-editing technology is widely used in avian breeding, the identification of avian ISGs and the elucidation of their molecular mechanism may provide important support for the breeding of avians for disease resistance.

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Avian Reovirus: From Molecular Biology to Pathogenesis and Control

Nour,

Mohanty

2024

Viruses

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Avian reoviruses (ARVs) represent a significant economic burden on the poultry industry due to their widespread prevalence and potential pathogenicity. These viruses, capable of infecting a diverse range of avian species, can lead to a variety of clinical manifestations, most notably tenosynovitis/arthritis. While many ARV strains are asymptomatic, pathogenic variants can cause severe inflammation and tissue damage in organs such as the tendons, heart, and liver. In broilers and turkeys, ARVs can induce severe arthritis/tenosynovitis, characterized by swollen hock joints and lesions in the gastrocnemius tendons. Additionally, ARVs have been implicated in other diseases, although their precise role in these conditions remains to be fully elucidated. In recent years, ARV cases have surged in the United States, emphasizing the need for effective control measures. Routine vaccination with commercial or autogenous vaccines is currently the primary strategy for mitigating ARV’s impact. Future research efforts should focus on enhancing our understanding of ARV-induced pathogenesis, identifying host factors that influence disease severity, and developing novel vaccines based on ongoing surveillance of circulating ARV strains. This review aims to explore the molecular aspects of ARV, including virus structure, replication, molecular epidemiology, the roles of its encoded proteins in host pathogenesis, and the immune response to ARV infection. Furthermore, we discuss the diagnostic approaches of avian reovirus and the potential biosecurity measures and vaccination trials in combating ARV and developing effective antiviral strategies.

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IFI16 plays a critical role in avian reovirus induced cellular immunosuppression and suppresses virus replication

Cited by 3 publications

References 30 publications

Reconstruction of Avian Reovirus History and Dispersal Patterns: A Phylodynamic Study

Reconstruction of Avian Reovirus History and Dispersal Patterns: A Phylodynamic Study

Antiviral Effects of Avian Interferon-Stimulated Genes

Avian Reovirus: From Molecular Biology to Pathogenesis and Control

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