IFITM1 plays an essential role in the antiproliferative action of interferon-γ

Yang, Guohua; Xu, Yi; Chen, X; Hu, Gengxi

doi:10.1038/sj.onc.1209807

Cited by 121 publications

(129 citation statements)

References 59 publications

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“…Microarray analysis revealed 17 IFN-induced genes (underlined) [33][34][35][36][37][38] among the 20 most up-regulated genes (Table I). This result suggests that the secretion of IFN by tumor cells following HVJ-E treatment might stimulate IFNrelated genes.…”

Section: Resultsmentioning

confidence: 99%

“…35 Interferon induced transmembrane protein 1 (IFITM1) and interferon-induced protein with tetratricopeptide repeats 3 (IFIT3, also called RIG-G) are reported to generate anti-proliferation activity. 36,37 These 3 proteins presumably assist cancer cell death. Interferon-induced with helicase C domain 1 (IFIH1) and DEAD box polypeptide 58 (DDX58) are also called MDA-5 and RIG-I that are cytoplasmic receptors of cytomegalovirus and Sendai virus, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Efficient eradication of hormone‐resistant human prostate cancers by inactivated Sendai virus particle

Kawaguchi

Miyamoto

Inoue

et al. 2009

Intl Journal of Cancer

138

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Hormone-refractory prostate cancer is one of the intractable human cancers in the world. Here, we examined the direct tumorkilling activity of inactivated Sendai virus particle [hemagglutinating virus of Japan envelope (HVJ-E)] through induction of Type I interferon (IFN) in the hormone-resistant human prostate cancer cell lines PC3 and DU145. Preferential binding of HVJ-E to PC3 and DU145 over hormone-sensitive prostate cancer cell and normal prostate epithelium was observed, resulting in a number of fused cells. After HVJ-E treatment, a number of IFNrelated genes were up-regulated, resulting in Type I IFN production in PC3 cells. Then, retinoic acid-inducible gene-I (RIG-I) helicase which activates Type I IFN expression after Sendai virus infection was up-regulated in cancer cells after HVJ-E treatment. Produced IFN-a and -b enhanced caspase 8 expression via Janus kinases/Signal Transducers and Activators of Transcription pathway, activated caspase 3 and induced apoptosis in cancer cells. When HVJ-E was directly injected into a mass of PC3 tumor cells in SCID (severe combined immunodeficiency) mice, a marked reduction in the bulk of each tumor mass was observed and 85% of the mice became tumor-free. Although co-injection of an antiasialo GM1 antibody with HVJ-E into each tumor mass slightly attenuated the tumor suppressive activity of HVJ-E, significant suppression of tumor growth was observed even in the presence of anti-asialo GM1 antibody. This suggests that natural killer cell activation made small contribution to tumor regression following HVJ-E treatment in hormone-resistant prostate cancer model in vivo. Thus, HVJ-E effectively targets hormone-resistant prostate cancer by inducing apoptosis in tumor cells, as well as activating anti-tumor immunity. '

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Efficient eradication of hormone‐resistant human prostate cancers by inactivated Sendai virus particle

Kawaguchi

Miyamoto

Inoue

et al. 2009

Intl Journal of Cancer

138

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“…40 The antiproliferative action of IFN requires the induction of IFITM2, and provides a crosstalk between 2 well-known signaling mediators, STAT1 and p53, both of which play critical roles in tumor suppression. 39 In solid tumors, IFITM2 gene expression is significantly up-regulated specifically in colorectal tumors, and thus may be a useful diagnostic marker in these tumors. 24 In this study, IFITM2 and IFITM3 were coexpressed and both up-regulated in good responsive tumors.…”

Section: Discussionmentioning

confidence: 99%

“…All these data point to a hypothesis that IFITM2 is a negative regulator of cell proliferation. 39 Recently, it was suggested that high IFITM2 expression correlated with improved survival in chronic myeloid leukemia patients. 40 The antiproliferative action of IFN requires the induction of IFITM2, and provides a crosstalk between 2 well-known signaling mediators, STAT1 and p53, both of which play critical roles in tumor suppression.…”

Section: Discussionmentioning

confidence: 99%

Molecular characterization of the response to chemotherapy in conventional osteosarcomas: Predictive value of HSD17B10 and IFITM2

Salas

Jézéquel²,

Campion

et al. 2009

Intl Journal of Cancer

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The therapy regimen of high-grade osteosarcoma includes chemotherapy followed by surgical resection and postoperative chemotherapy. The degree of necrosis following definitive surgery remains the only reliable prognostic factor and is used to guide the choice of postoperative chemotherapy. The aim of this study was to find molecular markers able to classify patients with an osteosarcoma as good or poor responders to chemotherapy before beginning treatment. Gene expression screening of 20 nonmetastatic high-grade osteosarcoma patients was performed using cDNA microarray. Expression of selected relevant genes was validated using QRT-PCR. Immunohistochemistry on tissue microarrays sections of 73 biopsies was performed to investigate protein expression. Fluorescent in situ hybridization was performed for RPL8 gene. We have found that HSD17B10 gene expression was up-regulated in poor responders and that immunohistochemistry expression of HSD17B10 on biopsy before treatment was correlated to response to chemotherapy. Other results include correlation of IFITM2, IFITM3, and RPL8 gene expression to chemotherapy response. A statistical correlation was found between polysomy 8 or gain of RPL8 and good response to chemotherapy. These data suggest that HSD17B10, RPL8, IFITM2, and IFITM3 genes are involved in the response to the chemotherapy and that HSD17B10 may be a therapeutic target. RPL8 and IFITM2 may be useful in the assessment at diagnosis and for stratifying patients taking part in randomized trials. ' 2009 UICC

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“…Suppression of IFITM1 has been shown to block the anti-proliferative effect of IFN-gamma, accelerate the cell growth rate and confer tumorigenicity to a non-malignant hepatocyte cell line in nude mice [18]. IFITM1 is a component of a multimeric complex involved in the transduction of anti-proliferative signals.…”

Section: Discussionmentioning

confidence: 99%

Differential gene expression identified in Uigur women cervical squamous cell carcinoma by suppression subtractive hybridization

Pan

Chen²,

X³

et al. 2010

neo

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Cervical cancer is one of the most common gynecological cancers worldwide. Over the past decade, much progress has been made in understanding the genetic changes associated with the development and progression of cervical cancer. However, the precise mechanisms of cervical carcinogenesis in Uigur women remain unclear. To screen differential gene expression in squamous cell carcinoma (SCC) of the cervix in Uigur women, suppressive subtractive hybridization (SSH) was performed on the cervical squamous cell carcinoma and corresponding normal cervical tissues of a Uigur patient. Thus we were be able to find the genes that are related with cervical tumors of Uigur women. A total of 300 samples were subject to DNA sequencing analysis and 46 genes were found to express differentially in tumors compared with normal tissues. Of the 46 genes, 24 genes were up-regulated whereas 22 genes were down-regulated in cervical tumors. The expression profiles of 5 of the 46 genes were further confirmed in 15 other Uigur patients by semi-quantitative reverse-transcription polymerase chain reaction. Our results revealed that ACADVL, CEBPB, IFITM1 and DNAJC9 are involved in cervical carcinogenesis.

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IFITM1 plays an essential role in the antiproliferative action of interferon-γ

Cited by 121 publications

References 59 publications

Efficient eradication of hormone‐resistant human prostate cancers by inactivated Sendai virus particle

Efficient eradication of hormone‐resistant human prostate cancers by inactivated Sendai virus particle

Molecular characterization of the response to chemotherapy in conventional osteosarcomas: Predictive value of HSD17B10 and IFITM2

Differential gene expression identified in Uigur women cervical squamous cell carcinoma by suppression subtractive hybridization

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