2012
DOI: 10.1002/ppul.22540
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IFN‐γ and IP‐10 in tracheal aspirates from premature infants: Relationship with bronchopulmonary dysplasia

Abstract: BackgroundInterferon‐gamma (IFN‐γ) and interferon‐inducible protein of 10 kDa (IP‐10) are potent inflammatory mediators and contribute to acute lung injury in adults. Recently, a potential role for IFN‐γ and IP‐10 in the pathogenesis of bronchopulmonary dysplasia (BPD) has been reported in animal models.ObjectiveTo study the association between IFN‐γ and IP‐10 in tracheal aspirate (TA) and the development of BPD in premature infants.Design/MethodsTA samples collected within 48 hr after birth from 79 mechanical… Show more

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Cited by 27 publications
(20 citation statements)
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“…24 The levels of IL-6 in the serum and TA fluid were measured using commercially available enzyme-linked immunosorbent assay (ELISA; R&D Systems, Minneapolis, MN, USA) according to the manufacturer's instructions. The oxidative stress marker formation of 8-OHdG by oxygen radicals was measured using a highly sensitive 8-OHdG ELISA kit (JalCA, Fukuroi, Shizuoka, Japan).…”
Section: Enzyme-linked Immunosorbent Assaymentioning
confidence: 99%
“…24 The levels of IL-6 in the serum and TA fluid were measured using commercially available enzyme-linked immunosorbent assay (ELISA; R&D Systems, Minneapolis, MN, USA) according to the manufacturer's instructions. The oxidative stress marker formation of 8-OHdG by oxygen radicals was measured using a highly sensitive 8-OHdG ELISA kit (JalCA, Fukuroi, Shizuoka, Japan).…”
Section: Enzyme-linked Immunosorbent Assaymentioning
confidence: 99%
“…Elevated levels of interferon (IFN)-␥ have been seen in tracheal aspirates of human subjects with BPD, prompting investigation in transgenic mouse models (2,35). Overexpression of IFN-␥ was induced in the lungs of newborn mice in the saccular stage of lung development, which resulted in increased markers of apoptosis, including caspases 3, 8, and 9.…”
Section: Rodent Models Of Pulmonary Diseasementioning
confidence: 99%
“…BPD has a complex and multifactorial etiology, including oxygen toxicity, preterm delivery, hypoxia/ hyperoxia, infection, and inflammation (5)(6)(7). Many studies have suggested that BPD is a result of imbalance between proinflammatory and anti-inflammatory mechanisms (8,9).…”
mentioning
confidence: 99%