IFN-γ and YAP lead epithelial cells astray after severe respiratory infection
Bradley E. Hiller,
Joseph P. Mizgerd
Abstract:Ineffective recovery from pneumonia can lead to interstitial lung disease characterized by aberrant epithelial cells in fibrotic regions. In this issue of the
JCI
, Lin et al. define molecular pathways leading to the development and persistence of keratin 5
+
(Krt5
+
) epithelial cells in the alveolar parenchyma when mice struggle to recover from influenza infection. The receptor for IFN-γ on lung epithelium was essential for the formation of… Show more
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